Oct, 2002
Antimalarial activity of yingzhaosu A analogues
JOURNAL OF MEDICINAL CHEMISTRY
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- Volume
- 45
- Number
- 21
- First page
- 4732
- Last page
- 4736
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1021/jm020208q
- Publisher
- AMER CHEMICAL SOC
Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.
- Link information
- ID information
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- DOI : 10.1021/jm020208q
- ISSN : 0022-2623
- Web of Science ID : WOS:000178466600016