論文

国際誌
2022年3月

Dynamic balance deficit and the neural network in Alzheimer's disease and mild cognitive impairment.

Gait & posture
  • Ryotaro Ide
  • ,
  • Miho Ota
  • ,
  • Yasushi Hada
  • ,
  • Serina Watanabe
  • ,
  • Takumi Takahashi
  • ,
  • Masashi Tamura
  • ,
  • Kiyotaka Nemoto
  • ,
  • Tetsuaki Arai

93
開始ページ
252
終了ページ
258
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.gaitpost.2022.01.018

BACKGROUND: Patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) exhibit balance deficits. Although only a few studies have evaluated the relationship between the brain images and balance indices. In this study, we measured balance indices, including the index of postural stability (IPS) and assessed the relationship between the brain images and their clinical motor and cognitive functional features. METHODS: The study included patients with MCI (N = 14) and patients with AD (N = 19). The primary outcome was IPS under a visual block condition and/or a proprioception block condition. In addition, 9 MCI and 8 AD patients underwent a 1.5-Tesla (1.5-T) Magnetic Resonance Imaging (MRI) scan, and the relationships between the MRI parameters and the balance indices were evaluated. RESULTS: The IPS score was significantly lower in the AD group than the MCI group, but only under the closed eyes/hard surface condition. In terms of MRI, there was a significant positive correlation between the IPS and the regional betweenness centrality in the left hippocampal region. CONCLUSIONS: The finding of a significantly lower IPS score under the closed eyes/hard surface condition in AD than in MCI cases suggests that the vestibular and/or proprioceptive systems were more severely impaired in AD than MCI cases. The results suggest that a dynamic balance disturbance due to deficits of the vestibular hippocampal pathway may be a useful marker for the diagnosis of MCI and detection of disease progression from MCI to AD.

リンク情報
DOI
https://doi.org/10.1016/j.gaitpost.2022.01.018
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35227962
ID情報
  • DOI : 10.1016/j.gaitpost.2022.01.018
  • PubMed ID : 35227962

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