2011年8月
CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads
Journal of Cell Communication and Signaling
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- 巻
- 5
- 号
- 3
- 開始ページ
- 167
- 終了ページ
- 171
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12079-011-0135-1
Chondrocytes forming articular cartilage are embedded in a vast amount of extracellular matrix having physical stiffness and elasticity, properties that support the mechanical load from bones and enable the flexible movement of synovial joints. Unlike chondrocytes that conduct the growth of long bones by forming the growth plate, articular chondrocytes show suppressed cell proliferation, unless these cells are exposed to pathological conditions such as mechanical overload. In the present study, we found that one of the members of the CCN family, CCN3, was significantly expressed in chondrocytes isolated from the epiphyseal head in developing rat synovial joints. Evaluation of the effect of recombinant CCN3 on those chondrocytes revealed that CCN3 promoted proteoglycan synthesis, whereas this factor repressed the proliferation of the same cells. These results suggest a critical role for CCN3 in the regulation of the biological properties of articular chondrocytes. © The International CCN Society 2011.
- ID情報
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- DOI : 10.1007/s12079-011-0135-1
- ISSN : 1873-9601
- ISSN : 1873-961X
- SCOPUS ID : 80055015744