2018年5月31日
Diffusion modulation of DNA by toehold exchange
Physical Review E
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- 巻
- 97
- 号
- 5
- 開始ページ
- 052617
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1103/PhysRevE.97.052617
- 出版者・発行元
- American Physical Society
We propose a method to control the diffusion speed of DNA molecules with a target sequence in a polymer solution. The interaction between solute DNA and diffusion-suppressing DNA that has been anchored to a polymer matrix is modulated by the concentration of the third DNA molecule called the competitor by a mechanism called toehold exchange. Experimental results show that the sequence-specific modulation of the diffusion coefficient is successfully achieved. The diffusion coefficient can be modulated up to sixfold by changing the concentration of the competitor. The specificity of the modulation is also verified under the coexistence of a set of DNA with noninteracting base sequences. With this mechanism, we are able to control the diffusion coefficient of individual DNA species by the concentration of another DNA species. This methodology introduces a programmability to a DNA-based reaction-diffusion system.
- リンク情報
- ID情報
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- DOI : 10.1103/PhysRevE.97.052617
- ISSN : 2470-0053
- ISSN : 2470-0045
- PubMed ID : 29906997
- SCOPUS ID : 85048083403
- Web of Science ID : WOS:000433913900011