論文

査読有り 国際誌
2011年3月

Genetic contribution to the relationship between social role function and depressive symptoms in Japanese elderly twins: a twin study

PSYCHOGERIATRICS
  • Reiko Nishihara
  • ,
  • Fujio Inui
  • ,
  • Kenji Kato
  • ,
  • Rie Tomizawa
  • ,
  • Kazuo Hayakawa

11
1
開始ページ
19
終了ページ
27
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1479-8301.2010.00342.x
出版者・発行元
WILEY

Background:
Social role function is the capacity to maintain interpersonal relationships and is essential for being independent in the community. Limitations in social role function often coexist with depressive symptoms, suggesting a possible common mechanistic basis. We investigated whether the observed association between these traits is mainly a result of genetic or environmental influences.
Methods:
In 2008, a questionnaire was sent to 745 male twins aged 65 years and older. Our sample included 397 male twins. The number of monozygotic twins was 302, and dizygotic was 95. Among the twin pairs for whom data were available for both twins, 75 twin pairs (150 individuals) were monozygotic and 28 pairs (56 individuals) were dizygotic. Social role function was assessed using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Depressive symptoms were measured by the 15-item version of the Geriatric Depression Scale. Relative importance of genes and environments for the phenotypes was calculated using structural equation analyses.
Results:
Our results show that genetic influence was the major contributor to the relationship between social role function and depressive symptoms, and non-shared environmental influence was important for overall variation in each trait.
Conclusions:
We concluded that focusing on a non-shared environment is an essential approach for maintaining social role function and psychological well-being. It is suggested that treatments specific to depressive symptoms are more effective than indirect intervention targeting social role function.

リンク情報
DOI
https://doi.org/10.1111/j.1479-8301.2010.00342.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21447105
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000288949700004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1479-8301.2010.00342.x
  • ISSN : 1346-3500
  • eISSN : 1479-8301
  • PubMed ID : 21447105
  • Web of Science ID : WOS:000288949700004

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