The cognitive symptoms in early Alzheimer's disease (AD) involve problems with learning, memory or planning. Currently, no medical tests are available to conclusively diagnose dementia pre-mortem. Previous studies have demonstrated that the cognitive deficits of AD can be detected during a preclinical period with neuropsychological tests. This chapter's hypothesis is that cognitive deficit symptoms of AD are detectable using a combination of tactile, kinetic, cognitive, and functional MRI tasks in the earliest stages of the disease. The authors of this chapter offer a novel approach to investigate the early detection of AD with tactile procedures. This chapter introduces the development of two tactile pattern delivery devices. The first delivery device is MRI-compatible and can serve to investigate the underlying neural mechanisms of active and passive tactile pattern discrimination. The second delivery device is designed to investigate the characteristics of passive shape discrimination for psychological experiments. These devices may contribute to the early detection of AD with neuropsychological approaches. The ultimate goal of this research was to confirm the human ability of tactile shape discrimination and determine the differences between age-matched healthy individuals and AD patients. © 2011, IGI Global.