Ecosystem degradation and biodiversity loss have been caused by economic booms in developing countries over recent decades. In response, ecosystem restoration projects have been advanced in some countries but the effectiveness of different approaches and indicators at large spatio-temporal scales (i.e., whole catchments) remains poorly understood. This study assessed the effectiveness of a diverse array of 440 aquatic restoration projects including wastewater treatment, constructed wetlands, plant/algae salvage and dredging of contaminated sediments implemented and maintained from 2007 to 2017 across more than 2000 km2 of the northwest Taihu basin (Yixing, China). Synchronized investigations of water quality and invertebrate communities were conducted before and after restoration. Our analysis showed that even though there was rapid urbanization at this time, nutrient concentrations (NH4+-N, TN, TP) and biological indices of benthic invertebrate (taxonomic richness, Shannon diversity, sensitive taxon density) improved significantly across most of the study area. Improvements were associated with the type of restoration project, with projects targeting pollution-sources leading to the clearest ecosystem responses compared with those remediating pollution sinks. However, in some locations, the recovery of biotic communities appears to lag behind nutrients (e.g., nitrogen and phosphorus), likely reflecting long-distance re-colonization routes for invertebrates given the level of pre-restoration degradation of the catchment. Overall, the study suggests that ecological damage caused by recent rapid economic development in China could potentially be mitigated by massive restoration investments synchronized across whole catchments, although these effects could be expected to be enhanced if urbanization rates were reduced at the same time.