中村 純

An unexpected butadiene diolepoxide-mediated genotoxicity implies alternative mechanism for 1,3-butadiene carcinogenicity 

Chemosphere 266 129149-129149 2021年3月  査読有り筆頭著者責任著者

Potential doxorubicin-mediated dual-targeting chemotherapy in FANC/BRCA-deficient tumors via modulation of cellular formaldehyde concentration 

Chemical Research in Toxicology 33(10) 2659-2667 2020年9月2日  査読有り筆頭著者責任著者

New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis 

Vascular Pharmacology 133-134 106777-106777 2020年8月  査読有り

The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice 

Genes and Environment 42 21 2020年6月  査読有り筆頭著者責任著者

Retinoic Acid-Loaded Poly(lactic-co-glycolic acid) Nanoparticle Formulation of ApoB-100-Derived Peptide 210 Attenuates Atherosclerosis 

Journal of Biomedical Nanotechnology 16(4) 467-480 2020年4月  査読有り

DNA-protein crosslink formation by endogenous aldehydes and AP sites. 

DNA repair 88 102806-102806 2020年2月10日  査読有り筆頭著者責任著者

Development of a novel PIG-A gene mutation assay based on a GPI-anchored fluorescent protein sensor. 

Genes and environment : the official journal of the Japanese Environmental Mutagen Society 41 21-21 2019年  査読有り最終著者責任著者

Acid-specific formaldehyde donor is a potential, dual targeting cancer chemotherapeutic/chemo preventive drug for FANC/BRCA-mutant cancer. 

Genes and environment : the official journal of the Japanese Environmental Mutagen Society 41 23-23 2019年  査読有り最終著者責任著者

Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes. 

Scientific reports 7(1) 10787-10787 2017年9月7日  査読有り筆頭著者責任著者

A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity 

PLOS ONE 12(2) e0172172 2017年2月  査読有り最終著者責任著者

F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death 

FUTURE ONCOLOGY 12(19) 2183-2188 2016年10月  査読有り最終著者

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. 

Oncotarget 7(37) 59795-59808 2016年9月13日  査読有り最終著者責任著者

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations. 

Oncotarget 7(18) 25377-90 2016年5月3日  査読有り最終著者責任著者

Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium. 

PloS one 11(12) e0167503 2016年  査読有り最終著者責任著者

Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells. 

Mutagenesis 30(6) 821-8 2015年11月  査読有り最終著者責任著者

The endogenous exposome. 

DNA repair 19 3-13 2014年7月  査読有り筆頭著者

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. 

Blood 122(18) 3206-9 2013年10月31日  査読有り

A neutral glyoxal gel electrophoresis method for the detection and semi-quantitation of DNA single-strand breaks. 

Methods in molecular biology (Clifton, N.J.) 1054 133-143 2013年  査読有り最終著者責任著者

Evaluating the effects of bioremediation on genotoxicity of polycyclic aromatic hydrocarbon-contaminated soil using genetically engineered, higher eukaryotic cell lines. 

Environmental science & technology 46(8) 4607-13 2012年4月17日  査読有り責任著者

Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine. 

Chemical research in toxicology 25(3) 664-75 2012年3月19日  査読有り

Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell system. 

PloS one 7(3) e33563 2012年  査読有り筆頭著者責任著者

O-hydroxylamine-coupled alkaline gel electrophoresis assay for the detection and measurement of DNA single-strand breaks. 

Methods in molecular biology (Clifton, N.J.) 920 307-313 2012年  査読有り最終著者責任著者

Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action. 

Environmental and molecular mutagenesis 52(2) 153-60 2011年3月  査読有り最終著者責任著者

Accumulation of true single strand breaks and AP sites in base excision repair deficient cells. 

Mutation research 694(1-2) 65-71 2010年12月10日  査読有り最終著者責任著者

FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. 

Molecular cancer research : MCR 8(2) 204-15 2010年2月  査読有り最終著者

Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. 

Mutation research 671(1-2) 93-9 2009年12月1日  査読有り最終著者責任著者

Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment 

Environmental and Molecular Mutagenesis NA-NA 2009年  査読有り

Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. 

Cancer research 67(23) 11117-22 2007年12月1日  査読有り最終著者責任著者

Nonrandom AP site distribution in highly proliferative cells. 

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20(14) 2612-4 2006年12月  査読有り筆頭著者

XRCC1 genotype and breast cancer: Functional studies and epidemiologic data show interactions between XRCC1 condon 280 his and smoking 

CANCER RESEARCH 66(5) 2860-2868 2006年3月  査読有り最終著者責任著者

Effects of Naphthalene Quinonoids on the Induction of Oxidative DNA Damage and Cytotoxicity in Calf Thymus DNA and in Human Cultured Cells 

Chemical Research in Toxicology 18(8) 1262-1270 2005年8月  査読有り最終著者

Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene 

Carcinogenesis 25(9) 1727-1733 2004年4月1日  査読有り責任著者

Endogenous deoxyribonucleic Acid (DNA) damage in human tissues: a comparison of ethenobases with aldehydic DNA lesions. 

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 12(11 Pt 1) 1241-7 2003年11月  査読有り

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time 

NUCLEIC ACIDS RESEARCH 31(17) e104 2003年9月  査読有り筆頭著者責任著者

Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. 

Nucleic acids research 31(6) 1790-5 2003年3月15日  査読有り筆頭著者責任著者

5'-nicked apurinic/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress 

J. Biol. Chem. 275(8) 5323-5328 2000年2月25日  査読有り筆頭著者

Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues 

Cancer Res. 59(11) 2522-2526 1999年6月  査読有り筆頭著者

Highly Sensitive apurinic/apyrimidinic Site Assay Can Detect Spontaneous and Chemically Induced Depurination Under Physiological Conditions 

Cancer Research 58(2) 222-225 1998年1月  査読有り筆頭著者