Junko Kanoh

Profile Information

Affiliation: 教授, 大学院総合文化研究科広域科学専攻生命環境科学系, 東京大学

Degree: 博士（理学）(東京大学)

J-GLOBAL ID: 201801014752643414
researchmap Member ID: B000333879

東京大学理学部生物化学科卒業
東京大学大学院理学系研究科生物化学専攻修士課程
同上博士課程修了
東京大学医科学研究所ポスドク研究員
Scripps Research Institute ポスドク研究員
東京工業大学生命理工学研究科ポスドク研究員
同上助手
京都大学生命科学研究科助手／助教
大阪大学蛋白質研究所テニュアトラック准教授
同上独立准教授

東京大学大学院総合文化研究科広域科学専攻生命環境科学系　教授

Research Areas

Life sciences / Molecular biology /

Papers

Subtelomeres: hotspots of genome variation.

Junko Kanoh

Genes & genetic systems, 98(3) 155-160, Sep 30, 2023
Roles of Specialized Chromatin and DNA Structures at Subtelomeres in Schizosaccharomyces pombe.

Junko Kanoh

Biomolecules, 13(5), May 10, 2023
Complete sequences of Schizosaccharomyces pombe subtelomeres reveal multiple patterns of genome variation

Yusuke Oizumi, Takuto Kaji, Sanki Tashiro, Yumiko Takeshita, Yuko Date, Junko Kanoh

Nature Communications, 12(1), Dec, 2021
Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions.

Io Yamamoto, Hidenori Nakaoka, Masahiro Takikawa, Sanki Tashiro, Junko Kanoh, Tomoichiro Miyoshi, Fuyuki Ishikawa

Nucleic acids research, Sep 14, 2021
Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.

Haruna Inoue, Mayuri Horiguchi, Kota Ono, Junko Kanoh

Nucleic acids research, 47(13) 6871-6884, Jul 26, 2019 Peer-reviewed
Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins.

Yudai Hasegawa, Mayuko Yamamoto, Junki Miyamori, Junko Kanoh

Scientific reports, 9(1) 9946-9946, Jul 9, 2019 Peer-reviewed
Alpha satellite DNA-repeat OwlAlp1 forms centromeres in Azara's owl monkey.

Yusuke Oizumi, Akihiko Koga, Junko Kanoh

Genes to cells : devoted to molecular & cellular mechanisms, 24(7) 511-517, Jul, 2019 Peer-reviewed
Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.

Chunyi Hu, Haruna Inoue, Wenqi Sun, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh, Yong Chen

Nucleic acids research, 47(3) 1573-1584, Feb 20, 2019 Peer-reviewed
The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.

Chunyi Hu, Haruna Inoue, Wenqi Sun, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh, Yong Chen

Structure (London, England : 1993), 27(2) 335-343, Feb 5, 2019 Peer-reviewed
Unexpected roles of a shugoshin protein at subtelomeres.

Junko Kanoh

Genes & genetic systems, 92(3) 127-133, Jan 20, 2018 Peer-reviewed
Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.

Jing Xue, Hongwen Chen, Jian Wu, Miho Takeuchi, Haruna Inoue, Yanmei Liu, Hong Sun, Yong Chen, Junko Kanoh, Ming Lei

Cell research, 27(12) 1503-1520, Dec, 2017 Peer-reviewed
Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis.

Sanki Tashiro, Yuki Nishihara, Kazuto Kugou, Kunihiro Ohta, Junko Kanoh

Nucleic acids research, 45(18) 10333-10349, Oct 13, 2017 Peer-reviewed
[Unexpected roles of Shugoshin at chromosome ends].

Junko Kanoh

Seikagaku. The Journal of Japanese Biochemical Society, 89(1) 73-6, Feb, 2017 Peer-reviewed
CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.

Haruna Inoue, Shizuka Sugimoto, Yumiko Takeshita, Miho Takeuchi, Mitsuko Hatanaka, Koji Nagao, Takeshi Hayashi, Aya Kokubu, Mitsuhiro Yanagida, Junko Kanoh

Genes to cells : devoted to molecular & cellular mechanisms, 22(1) 59-70, Jan, 2017 Peer-reviewed
Telomeres and subtelomeres: new insights into the chromatin structures and functions of chromosome ends.

Junko Kanoh

Genes & genetic systems, 92(3) 105-105, 2017 Peer-reviewed
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka …

Nature communications, 7 10393-10393, Jan 25, 2016 Peer-reviewed
Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.

Wei Deng, Jian Wu, Feng Wang, Junko Kanoh, Pierre-Marie Dehe, Haruna Inoue, Juan Chen, Ming Lei

Cell research, 25(7) 881-4, Jul, 2015 Peer-reviewed
Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.

Yusuke Tarumoto, Junko Kanoh, Fuyuki Ishikawa

The Journal of biological chemistry, 288(26) 19260-8, Jun 28, 2013 Peer-reviewed
Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast.

Sanki Tashiro, Tomohiro Asano, Junko Kanoh, Fuyuki Ishikawa

Genes to cells : devoted to molecular & cellular mechanisms, 18(4) 327-39, Apr, 2013 Peer-reviewed
Release of chromosomes from the nuclear envelope: A universal mechanism for eukaryotic mitosis?

Junko Kanoh

Nucleus (United States), 4(2) 100-104, Mar, 2013 Peer-reviewed

Misc.

Novel functions of subtelomere

Junko Kanoh

GENES & GENETIC SYSTEMS, 89(6) 284-284, Dec, 2014
分裂酵母Cpc2はストレス応答性MAPキナーゼを介したストレス応答を促進する

樽本雄介, 加納純子, 加納純子, 上野敏秀, 間野博行, 間野博行, 石川冬木

日本分子生物学会年会プログラム・要旨集(Web), 35th, 2012
Closed mitosisの進行を保障するテロメア‐核膜ネットワーク

田中麻紀子, 辻井久代, 近重裕次, 渡邊祐三, 齋藤基輝, 石川冬木, 平岡泰, 加納純子

生化学, ROMBUNNO.4S12P-3, 2011
細胞分裂期におけるテロメアと核膜のネットワーク機能

辻井久代, 近重裕次, 渡邊祐三, 齋藤基輝, 石川冬木, 平岡泰, 加納純子

生化学, ROMBUNNO.1W8-6, 2010
The extreme terminus of chromosomes

Tomoichiro Miyoshi, Motoki Saito, Junko Kanoh, Fuyuki Ishikawa

GENES & GENETIC SYSTEMS, 82(6) 515-515, Dec, 2007
テロメアの最末端構造

三好知一郎, 齊藤基輝, 加納純子, 石川冬木

日本遺伝学会大会プログラム・予稿集, 79th, 2007
分裂酵母Cpc2はeIF2αキナーゼによるストレス応答に関与する

樽本雄介, 加納純子, 石川冬木

生化学, 2007
Ku蛋白質のS期におけるゲノム維持機構の解析

三好知一郎, 加納純子, 石川冬木

日本分子生物学会年会プログラム・講演要旨集, 27th, 2004
ATMのチェックポイントとテロメア維持における役割 (第5部 DNA損傷応答,チェックポイント機構とその破綻)

加納純子, 石川冬木

蛋白質核酸酵素, 46(8) 1194-1200, Jun, 2001
The gad7 gene is required for the G1 arrest in Schizosaccharomyces pombe.

KANO JUNKO, WATANABE YOSHINORI, OSUGI MIHO, IMAI YOSHIYUKI, IINO YUICHI, YAMAMOTO MASAYUKI

日本分子生物学会年会プログラム・講演要旨集, 17th 256, Nov, 1994

Research Projects

染色体末端サブテロメアの構造形成・機能制御メカニズム

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

加納純子
染色体末端特異的凝縮構造による非ゲノム情報維持機構

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2022 - Mar, 2024

加納純子
真核生物はなぜ線状の染色体をもつのか？

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2023

加納純子
サブテロメアクロマチンポテンシャル

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2021 - Mar, 2023

加納純子
染色体末端テロメア／サブテロメアの機能・構造維持メカニズム

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

加納純子
染色体末端特異的凝縮構造による非ゲノム情報維持機構

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2020 - Mar, 2022

加納純子
染色体末端構造を介したヒト科生物の進化原理の解明

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2019 - Mar, 2021

加納純子
サブテロメアクロマチンポテンシャルの分子メカニズム

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2019 - Mar, 2021

加納純子
Mechanism of the maintenance of functions and structure of chromosome ends

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Kanoh Junko
Regulatory mechanism of chromatin dynamics of subtelomere

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018
Elucidation of functions of telomere-adjacent regions

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Kanoh Junko
Novel genome-organization mechanism by telomere-binding proteins

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Kanoh Junko, HASEGAWA Yudai
The function of non-coding DNA for genome integrity

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Kobayashi Takehiko, NAKAYAMA Jun-ichi, OHTA Kunihiro, INNAN Hideki, KAJIKAWA Masaki, HISHIDA Takashi, Masumoto Hiroshi, KANOH Junko, TAKATA Minoru
Elucidation of functions of chromosome ends

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

KANOH JUNKO, TASHIRO Sanki, FUJITA Ikumi, NISHIHARA Yuki, INOUE Haruna, BAN Takuto, MIYASATO Kazumi, TANAKA Makiko, TAKESHITA Yumiko, TAKEUCHI Miho, SUGIMOTO Shizuka
Tel2-PIKKネットワークによるDNA修復反応と転写反応の統御メカニズム

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, 2011 - 2011

加納純子
Functions of telomere in chromosome segregation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

KANOH Junko
テロメア結合タンパク質群によるテロメアDNA長調節機構の解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2008 - 2009

加納純子
Tel2-PIKK相互作用ネットワークの解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2008 - 2009

加納純子
テロメアによる染色体維持機構の解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2006 - 2007

加納純子
分裂酵母テロメアの維持機構と核内配置に関する研究

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2005 - 2006

加納純子, 石川冬木

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