2015年8月
Mammalian blood odorant and chirality: synthesis and sensory evaluation by humans and mice of the racemate and enantiomers of trans-4,5-epoxy-(E)-2-decenal
TETRAHEDRON-ASYMMETRY
- ,
- ,
- 巻
- 26
- 号
- 15-16
- 開始ページ
- 861
- 終了ページ
- 867
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.tetasy.2015.06.011
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The racemate and enantiomers of trans-4,5-epoxy-(E)-2-decenal 1, an odorant with a metallic blood smell, were synthesized. The detection threshold for humans was 0.019 ppb for (2E,4S,5S)-(-)-1 and 0.62 ppb for (2E,4R,5R)-(+)-1, respectively. The racemate (+/-)-1 made mice scared stiff at a dosage of approximately 1 mg, while the enantiomers were not significantly bioactive. (C) 2015 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tetasy.2015.06.011
- ISSN : 0957-4166
- Web of Science ID : WOS:000360597100013