Pneumatic actuators have been widely utilized in various fields and have the important role for operating production facilities in plants with their advantages of light weight, low cost, safety, and high compliance. However, driving them needs not only the air supply line from compressor but also many electrical lines from valve controller, making the pneumatic drive system complicated. In this paper, we propose a new pneumatic control system using acoustic communication in an air supply line. This system needs two technical challenges; acoustic operating system and power supply device for each local module. This system realizes simple pneumatic drive system without electrical lines. This prototype system works very well to show the great potential of this proposed system. It controls successfully three pneumatic cylinders independently which are connected with an air supply line of 10[m] in length.