2011年8月
Cartilage Acidic Protein-1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation
SCIENCE
- 巻
- 333
- 号
- 6043
- 開始ページ
- 769
- 終了ページ
- 773
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.1204144
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent neural regeneration in the adult. LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse. A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation.
- リンク情報
-
- DOI
- https://doi.org/10.1126/science.1204144
- CiNii Articles
- http://ci.nii.ac.jp/naid/80021879973
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21817055
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000293512100047&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1126/science.1204144
- ISSN : 0036-8075
- CiNii Articles ID : 80021879973
- PubMed ID : 21817055
- Web of Science ID : WOS:000293512100047