論文

査読有り
2013年3月

Association of early post-procedure hemodynamic management with the outcomes of subarachnoid hemorrhage patients

JOURNAL OF NEUROLOGY
  • Kazuaki Kuwabara
  • ,
  • Kiyohide Fushimi
  • ,
  • Shinya Matsuda
  • ,
  • Koichi B. Ishikawa
  • ,
  • Hiromasa Horiguchi
  • ,
  • Kenji Fujimori

260
3
開始ページ
820
終了ページ
831
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00415-012-6710-4
出版者・発行元
SPRINGER HEIDELBERG

Post-procedure hemodynamic management for aneurysmal subarachnoid hemorrhage is controversial because of the paucity of studied patients. Using a Japanese administrative database, we tested whether increased albumin, catecholamine, and volumes of fluid administered between the procedure and the 4th post-procedure day would be associated with outcomes of mortality, consciousness deterioration at discharge and re-intubation between the 5th and 14th post-procedure days. Across 550 hospitals, 5,400 patients were identified who received clipping, wrapping and endovascular coiling within 48 h after admission in 2010. Patient characteristics and the administration of albumin, catecholamine, and volume of fluid normalized by body weight were analyzed among the groups and categorized according to the presence of albumin and catecholamine administered between the procedure and the 4th post-procedure day. The association of early hemodynamic management with outcomes was measured using logistic regression models, through controlling for the preference of early administration of albumin and catecholamine. For the patients, 9.3 % received albumin only, 14.4 % catecholamine only, and 4.9 % both between the procedure and the 4th post-procedure day, while 16.5 % received albumin or catecholamine on other days. Variation in albumin and catecholamine administration was observed. Higher normalized fluid volume, commenced before the 4th post-procedure day, was associated with increased mortality and re-intubation (although with decreased complications), and vice versa between the 4th and 14th post-procedure days. Catecholamine administration was associated with worsened outcomes. Hypervolemic and hypertensive therapies commenced before the 4th post-procedure day require further research to determine whether their associations with outcomes in this administrative data base are causal or not.

リンク情報
DOI
https://doi.org/10.1007/s00415-012-6710-4
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000316071400013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00415-012-6710-4
  • ISSN : 0340-5354
  • Web of Science ID : WOS:000316071400013

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