久保田弓子 (Yumiko Kubota) - マイポータル

基本情報

所属: 大阪大学理学研究科准教授

J-GLOBAL ID: 202001011011364436
researchmap会員ID: R000008293

研究キーワード

DNA複製

論文

Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts.

Kensuke Tatsukawa, Reihi Sakamoto, Yoshitaka Kawasoe, Yumiko Kubota, Toshiki Tsurimoto, Tatsuro S Takahashi, Eiji Ohashi

Nucleic acids research 2024年2月13日
Unique and shared functions of the Rad9–Hus1–Rad1 and Mre11–Rad50–Nbs1 complexes in ATR checkpoint activation and long-range DNA end resection inXenopusegg extracts

Kensuke Tatsukawa, Reihi Sakamoto, Yoshitaka Kawasoe, Yumiko Kubota, Toshiki Tsurimoto, Tatsuro S. Takahashi, Eiji Ohashi

2023年8月10日
Suppression of targeting of Dbf4-dependent kinase to pre-replicative complex in G0 nuclei.

Takuya Okada, Gaku Okabe, Yon-Soo Tak, Satoru Mimura, Haruhiko Takisawa, Yumiko Kubota

Genes to cells : devoted to molecular & cellular mechanisms 23(2) 94-104 2018年2月
MCM interference during licensing of DNA replication in Xenopus egg extracts-Possible Role of a C-terminal region of MCM3.

Satoru Mimura, Yumiko Kubota, Haruhiko Takisawa

Cell cycle (Georgetown, Tex.) 17(4) 492-505 2018年
RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts.

Yosuke Sanuki, Yumiko Kubota, Masato T Kanemaki, Tatsuro S Takahashi, Satoru Mimura, Haruhiko Takisawa

Cell cycle (Georgetown, Tex.) 14(7) 1010-23 2015年
Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio.

Minori Shinya, Daiki Machiki, Thorsten Henrich, Yumiko Kubota, Haruhiko Takisawa, Satoru Mimura

Cell cycle (Georgetown, Tex.) 13(20) 3271-81 2014年
Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interaction.

Seiji Tanaka, Yayoi Komeda, Toshiko Umemori, Yumiko Kubota, Haruhiko Takisawa, Hiroyuki Araki

Molecular and cellular biology 33(13) 2614-22 2013年7月
The prereplication complex recruits XEco2 to chromatin to promote cohesin acetylation in Xenopus egg extracts.

Torahiko L Higashi, Megumi Ikeda, Hiroshi Tanaka, Takuro Nakagawa, Masashige Bando, Katsuhiko Shirahige, Yumiko Kubota, Haruhiko Takisawa, Hisao Masukata, Tatsuro S Takahashi

Current biology : CB 22(11) 977-88 2012年6月5日
Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing.

Koji L Ode, Koichi Fujimoto, Yumiko Kubota, Haruhiko Takisawa

Genes to cells : devoted to molecular & cellular mechanisms 16(4) 380-96 2011年4月
Replisome progression complex links DNA replication to sister chromatid cohesion in Xenopus egg extracts.

Hiroshi Tanaka, Yumiko Kubota, Tsuyoshi Tsujimura, Maya Kumano, Hisao Masai, Haruhiko Takisawa

Genes to cells : devoted to molecular & cellular mechanisms 14(8) 949-63 2009年8月
Structure of the human GINS complex and its assembly and functional interface in replication initiation

Katsuhiko Kamada, Yumiko Kubota, Toshiaki Arata, Yosuke Shindo, Fumio Hanaoka

NATURE STRUCTURAL & MOLECULAR BIOLOGY 14(5) 388-396 2007年5月査読有り
Structure of the human GINS complex and its assembly and functional interface in replication initiation.

Katsuhiko Kamada, Yumiko Kubota, Toshiaki Arata, Yosuke Shindo, Fumio Hanaoka

Nature structural & molecular biology 14(5) 388-96 2007年5月査読有り
The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication.

Kumiko Matsuno, Maya Kumano, Yumiko Kubota, Yoshitami Hashimoto, Haruhiko Takisawa

Molecular and cellular biology 26(13) 4843-52 2006年7月
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

Marcin Pacek, Antonin V Tutter, Yumiko Kubota, Haruhiko Takisawa, Johannes C Walter

Molecular cell 21(4) 581-7 2006年2月17日
Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs.

Kazumasa Yoshida, Haruhiko Takisawa, Yumiko Kubota

Genes to cells : devoted to molecular & cellular mechanisms 10(1) 63-73 2005年1月
A role of xenopus geminin in the licensing of DNA replication

Kazumasa Yoshida, Yumiko Kubota, Haruhiko Takisawa

CELL STRUCTURE AND FUNCTION 29 61-61 2004年5月
A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication.

Yumiko Kubota, Youhei Takase, Yasunori Komori, Yoshitami Hashimoto, Toshiaki Arata, Yoichiro Kamimura, Hiroyuki Araki, Haruhiko Takisawa

Genes & development 17(9) 1141-52 2003年5月1日
Block to DNA replication in meiotic maturation: a unified view for a robust arrest of cell cycle in oocytes and somatic cells.

Yumiko Kubota, Haruhiko Takisawa

BioEssays : news and reviews in molecular, cellular and developmental biology 25(4) 313-6 2003年4月

担当経験のある科目(授業)

2020年4月 - 現在

生物学序論 (大阪大学)
ゲノム分子生物学 (大阪大学)

共同研究・競争的資金等の研究課題

中心体の分配と細胞質分裂の共役に関与する蛋白質の単離解析

日本学術振興会科学研究費助成事業若手研究(B) 2002年 - 2003年

久保田弓子
細胞周期に依存したMCM3及びMCM3の核移行活性の制御

日本学術振興会科学研究費助成事業奨励研究(A) 1999年 - 2000年

久保田弓子