Kazuro Shimokawa

Profile Information

Affiliation: Osaka University
: 非常勤講師, 東北大学
: 非常勤講師, 東京医科歯科大学

Degree: 博士（工学）

J-GLOBAL ID: 201801002324332694
researchmap Member ID: B000306485

Research Areas

Informatics / Biological, health, and medical informatics /

Awards

2000

入賞, 神経細胞の立体形状を考慮した神経興奮現象のシミュレーションと可視化, 第6回CVC/シンポジウム2000 （可視化コンテスト）

下川和郎, 村木茂

Papers

Genetic intratumour heterogeneity and clonal evolution in extramammary Paget’s disease

Kenichiro Tanaka, Ikko Kajihara, Kazuro Shimokawa, Naotoshi Nakamura, Yudo Kusaba, Ryoko Sakamoto, Saki Maeda-Otsuka, Saori Yamada-Kanazawa, Soichiro Sawamura, Hisashi Kanemaru …

European Journal of Dermatology, Dec, 2023 Peer-reviewed
A knowledge representation model for family relationship to three generation

Kazuro Shimokawa, Mami Ishikuro, Taku Obara, Hirohito Metoki, Satoshi Mizuno, Satoshi Nagaie, Masato Nagai, Chizuru Yamanaka, Hiroko Matsubara, Mayumi Kato …

Bioinformation, 18(12) 1166-1172, Dec 31, 2022 Peer-reviewedLead authorCorresponding author
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura …

Human Genome Variation, 8(1), Dec, 2021 Peer-reviewed
Artificial intelligence based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer's disease

Shingo Tsuji, Takeshi Hase, Ayako Yachie-Kinoshita, Taiko Nishino, Samik Ghosh, Masataka Kikuchi, Kazuro Shimokawa, Hiroyuki Aburatani, Hiroaki Kitano, Hiroshi Tanaka

Alzheimer's Research & Therapy, Apr, 2021 Peer-reviewed
Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals

Yumi Yamaguchi-Kabata, Jun Yasuda, Akira Uruno, Kazuro Shimokawa, Seizo Koshiba, Yoichi Suzuki, Nobuo Fuse, Hiroshi Kawame, Shu Tadaka, Masao Nagasaki …

Human Genetics, Mar, 2019 Peer-reviewed
Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing

Yusuke Shibuya, Hideki Tokunaga, Sakae Saito, Kazuro Shimokawa, Fumiki Katsuoka, Li Bin, Kaname Kojima, Masao Nagasaki, Masayuki Yamamoto, Nobuo Yaegashi …

GENES CHROMOSOMES & CANCER, 57(2) 51-60, Feb, 2018 Peer-reviewed
ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks

Morita, Masahiko, Shimokawa, Kazuro, Nishimura, Masaomi, Nakamura, Sakiko, Tsujimura, Yuki, Takemoto, Satoko, Tawara, Takehiro, Yokota, Hideo, Wemler, Shuhei, Miyamoto, Daisuke …

Nucleic Acid Research Database Issue, 47(Database-Issue)-866, 2018 Peer-reviewed
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Norihiro Kato, Marie Loh, Fumihiko Takeuchi, Niek Verweij, Xu Wang, Weihua Zhang, Tanika N. Kelly, Danish Saleheen, Benjamin Lehne, Irene Mateo Leach …

NATURE GENETICS, 47(11) 1282-+, Nov, 2015 Peer-reviewed
Integrated Database and Knowledge Base for Genomic Prospective Cohort Study in Tohoku Medical Megabank Toward Personalized Prevention and Medicine

Soichi Ogishima, Takako Takai, Kazuro Shimokawa, Satoshi Nagaie, Hiroshi Tanaka, Jun Nakaya

Studies in Health Technology and Informatics, 216 1057, 2015 Peer-reviewed
Broad Integration of Expression Maps and Co-Expression Networks Compassing Novel Gene Functions in the Brain

Yuko Okamura-Oho, Kazuro Shimokawa, Masaomi Nishimura, Satoko Takemoto, Akira Sato, Teiichi Furuichi, Hideo Yokota

SCIENTIFIC REPORTS, 4 6969, Nov, 2014 Peer-reviewed
Identification of a genetic variant at 2q12.1 associated with blood pressure in East-Asians by genome-wide scan including gene-environment interactions

Yun Kyoung Kim, Youngdoe Kim, Mi Yeong Hwang, Kazuro Shimokawa, Sungho Won, Norihiro Kato, Yasuharu Tabara, Mitsuhiro Yokota, Bok-Ghee Han, Jong Ho Lee …

BMC MEDICAL GENETICS, 15(1) 65, Jun, 2014 Peer-reviewed
Integrated Analysis of Anatomical Gene Expression Maps and Co-Expression Networks Using a Database, ViBrism

Okamura-Oho Yuko, Shimokawa Kazuro, Takemoto Satoko, Song Gang, Gee James, Yokota Hideo

Frontiers in Neuroinformatics, 8, 2014
Novel genes located in the co-expression networks detected with Transcriptome Tomography

Okamura-Oho Yuko, Shimokawa Kazuro, Nishimura Masaomi, Takemoto Satoko, Sato Akira, Furuichi Teiichi, Yokota Hideo

Frontiers in Neuroinformatics, 8, 2014
Developmentally Conserved Brain Designs Quantifiable with Transcriptome Tomography

Okamura-Oho Yuko, Shimokawa Kazuro, Takemoto Satoko, Yokota Hideo

Frontiers in Neuroinformatics, 7, 2013
Transcriptome Tomography for Brain Analysis in the Web-Accessible Anatomical Space

Yuko Okamura-Oho, Kazuro Shimokawa, Satoko Takemoto, Asami Hirakiyama, Sakiko Nakamura, Yuki Tsujimura, Masaomi Nishimura, Takeya Kasukawa, Koh-hei Masumoto, Itoshi Nikaido …

PLOS ONE, 7(9), Sep, 2012 Peer-reviewed
Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals

Fumihiko Takeuchi, Masato Isono, Tomohiro Katsuya, Mitsuhiro Yokota, Ken Yamamoto, Toru Nabika, Kazuro Shimokawa, Eitaro Nakashima, Takao Sugiyama, Hiromi Rakugi …

PLOS ONE, 7(9), Sep, 2012 Peer-reviewed
Screening for Epigenetically Masked Genes in Colorectal Cancer Using 5-Aza-2 '-deoxycytidine, Microarray and Gene Expression Profile

Ahmed Khamas, Toshiaki Ishikawa, Kazuro Shimokawa, Kaoru Mogushi, Satoru Iida, Megumi Ishiguro, Hiroshi Mizushima, Hiroshi Tanaka, Hiroyuki Uetake, Kenichi Sugihara

CANCER GENOMICS & PROTEOMICS, 9(2) 67-75, Mar, 2012 Peer-reviewed
iCOD: an integrated clinical omics database based on the systems-pathology view of disease

Kazuro Shimokawa, Kaoru Mogushi, Satoshi Shoji, Atsuko Hiraishi, Keisuke Ido, Hiroshi Mizushima, Hiroshi Tanaka

BMC GENOMICS, 11, Dec, 2010 Peer-reviewed
Clinical Omics Analysis of Colorectal Cancer Incorporating Copy Number Aberration and Gene Expression Data

Yoshida T, Kobayashi T, Itoda M, Muto T, Miyaguchi K, Mogushi K, Shoji S, Shimokawa K, Iida S, Uetake H …

Cancer Informatics, 9 147-161, 2010 Peer-reviewed
Expression analysis for inverted effects of serotonin transporter inactivation

Manabu Ichikawa, Yuko Okamura-Oho, Kazuro Shimokawa, Shinji Kondo, Sakiko Nakamura, Hideo Yokota, Ryutaro Himeno, Klaus-Peter Lesch, Yoshihide Hayashizaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 368(1) 43-49, Mar, 2008 Peer-reviewed

Misc.

三世代コホート調査における調査票結果回付における情報管理について

永家聖, 永家聖, 下川和郎, 佐藤ゆき, 石黒真美, 水野聖士, 宮下真子, 山中千鶴, 目時弘仁, 荻島創一 …

日本疫学会学術総会講演集(Web), 27th, 2017
ViBrism-DBデータセットを用いた遺伝子発現地図と共発現ネットワークの統合解析で明らかになった発生学的に保存された脳の意匠

於保祐子, 於保祐子, 下川和郎, 竹本智子, 横田秀夫

日本分子生物学会年会プログラム・要旨集(Web), 36th, 2013
Identification of epigenetically silenced tumor suppressor genes in colorectal cancer

Ahmed Khamas, Toshiaki Ishikawa, Satoru Iida, Megumi Ishiguro, Kazuro Shimokawa, Hiroshi Mizushima, Hiroyuki Uetake, Kenichi Sugihara

CANCER RESEARCH, 71, Sep, 2011
Genome-wide analysis of mammalian promoter architecture and evolution (vol 38, pg 626, 2006)

Piero Carninci, Albin Sandelin, Boris Lenhard, Shintaro Katayama, Kazuro Shimokawa, Jasmina Ponjavic, Colin A. M. Semple, Martin S. Taylor, Paer G. Engstroem, Martin C. Frith …

NATURE GENETICS, 39(9) 1174-1174, Sep, 2007

Books and Other Publications

DNA microarrays

Kazuro Shimokawa (Role: Joint author, PP. 103-114)

Scion Publishing., 2008
蛋白質核酸酵素増刊号「ゲノムネットワーク」

下川和郎 (Role: Joint author, 遺伝子発現解析データーベース)

共立出版, 2004
神経システムの大規模シミュレーションを目指して

村木茂, 下川和郎, 緒方正人, 梶原景範, Kwan-Liu M (Role: Joint author, pp 58-65)

共立出版, 2001

Presentations

Person trip survey and simulation analysis of outpatient visit.

Kazuro Shimokawa, Hiroshi Tanaka

AROB2021, Jan 23, 2021
メンデルランダム化解析による因果関係の推定とゲノムワイド関連解析の重要性

下川和郎, 成田暁, 田中博, 鈴木貴

応用数理学会, Mar 5, 2020 Invited
Whole genome association study based on the questionnaire data for examining the relation among genome, food preference and environmental factors. ~Causal relation between Food Preference and their Intakes.~

Kazuro Shimokawa, Hiroshi Tanaka

Jan 23, 2019
食と健康に関わる大規模集団研究

下川和郎

JASIS 2018, Sep 6, 2018 Invited
Whole genome association study based on the questionnaire data to examine the relation among genome, food preference, environment and genetic factors

Kazuro Shimokawa, Yuki Sato, Yuko Okamura-Oho, Akira Narita, Jun Yasuda, Hiroshi Tanaka

SLLS, Jul, 2018
ViBrism database for gene expression maps and co-expression networks analysis on the 3D brain

Kazuro Shimokawa, Masahiko Morita, Masaomi Nishimura, Hideo Yokota, Shuhei Wemler, Yoshihiro Okumura, Yoko Yamaguchi, Yuko Okamura-Oho

Neuroscience, Nov, 2017
ゲノムから個人に適した食事の助言を考える

下川和郎

JASIS 2017, Sep 7, 2017 Invited
Anatomical and topological expression analysis of the mouse transcriptome in the virtual 3D MRI image spaces of the postnatal brain stages

Morita M, Yuko Okamura-Oho, Shimokawa K

Neuroinformatics, 2016
Data structure of three generation families in cohort study : for recruiting and retrieving

Shimokawa K, Metoki H, Takai T, Ogishima S, Ishikuro M, Mizuno S, Nagaie S, Obara T, Sato Y, Miyashita M, Yamanaka C, Kikuya M, Kuriyama S, Tanaka H

ASHG annual meeting, 2016
Network analysis of 3D gene expression pattern, using microtomy based transcriptomic data sets in ViBrism DB

Shimokawa K, Morita M, Nishimura M, Yokota H, Okamura-Oho Y

Neuroinformatics, 2015
Transcriptome Tomography: Mapping Genes onto 3D Brain Structures.

Yuko Okamura-Oho, Kazuro Shimokawa, Sakiko Nakamura, Yuki Tsujimura, Masaomi Nishimura, Satoko Takemoto, Masahiko Morita, Takashi Ijiri, Takehiro Tawara, Hideo Yokota

2014
Novel genes located in the co-expression networks detected with Transcriptome Tomography

Yuko Okamura-Oho, Shimokawa K

Neuroinformatics, 2014
Transdisease Omics analysis of Clinical data by SAGE

Shimokawa K, Sasaki Y, Tanaka H

CBI-KSBSB joint conference, 2009
Clustering Analysis of Human CAGE data to examine expression of Transcripts.

Shimokawa K, Oho Y, Carninci P, Shimada H, Suzuki H, Kawai J, Hayashizaki Y

20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., 2006
どういう人材が求められているのか？ -- 理研における研究者としての経験 --

下川和郎

CBI 学会, Aug 18, 2004 Invited
Next-Generation Visual Supercomputing using PC Clusters with Volume Graphics Hardware

Muraki S, Ogata M, Ma K, Koshizuka K, Kajihara K, Xuezhen L, Nagano Y, Shimokawa K

SC2001 Research Gems, 2001
VG Cluster: Large Scale Visual Computing System for Volumetric Simulations

Muraki S, Shimokawa K, Ogata M, Kajihara K, Ma K, Ishikawa Y

SC2000 Research Gems, 2000
Intermittent Firing of the Hodgkin Huxley Type Equation Considering Subthreshold Oscillation

Shimokawa K, Hanyu Y, Matsumoto G

5th International Conference on Soft Computing and Information/Intelligent Systems IIZUKA’98., 1998

Professional Memberships

Research Projects

食選択行動に影響するゲノム変異の網羅的関連解析と結果のモデル化

科学研究費助成事業, 文部科学省, Apr, 2021 - Mar, 2024

於保祐子, 下川和郎
生活習慣・食生活と遺伝子多様性との関係の網羅的解析

科学研究費助成事業, 文部科学省, Apr, 2016 - Mar, 2019

下川和郎
ヒト塩分摂取量と食品摂取行動に関する感受性遺伝子多型の関連解析と国際比較

ソルトサイエンス研究財団, Apr, 2017 - Mar, 2018

下川和郎
INCF 日本ノード 3D-ISMデジタル脳プラットフォーム（PF）の公開運用

社会知創成事業, 独立行政法人理化学研究所, Apr, 2014 - Mar, 2018

下川和郎

Industrial Property Rights

特開2007-06468 遺伝子発現画像構築方法および遺伝子発現画像構築システム

横田秀夫, 於保祐子, 下川和郎
特願06JP2016997 METHOD OF CONSTRUCTING GENE EXPRESSION IMAGE AND SYSTEM FOR CONSTRUCTING GENE EXPRESSION IMAGE

YOKOTA Hideo, OHO Yuko, SHIMOKAWA Kazuro

Profile Information

Research Areas

Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

Industrial Property Rights

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