2012年4月
Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study
GASTRIC CANCER
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 15
- 号
- 2
- 開始ページ
- 162
- 終了ページ
- 169
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10120-011-0092-7
- 出版者・発行元
- SPRINGER
The results of prospective studies examining the association between dietary vitamin A intake and the risk of gastric cancer have often been conflicting. The objective of this study was to investigate this issue in a general Japanese population.
A total of 2,467 community-dwelling Japanese subjects aged 40 years or older were followed up prospectively for 14 years. Dietary vitamin A intake was estimated using a semiquantitative food frequency method.
During the follow-up period, gastric cancer developed in 93 subjects. The age- and sex-adjusted incidence of gastric cancer rose progressively with increasing levels of dietary vitamin A intake: at 2.2, 3.0, 3.8, and 4.5 per 1,000 person-years for quartile groups defined by dietary vitamin A intake levels of < 639, 639-837, 838-1,061, and > 1,061 mu g retinol equivalents (RE)/day, respectively (P for trend < 0.01). The risk of gastric cancer was significantly higher in the fourth quartile than in the first one even after multivariate adjustment [hazard ratio (HR) = 1.47, 95% confidence interval (CI) = 0.70-3.09, P = 0.30 for the second quartile; HR = 1.85, 95% CI = 0.82-4.18, P = 0.14 for the third quartile; HR = 2.96, 95% CI = 1.12-7.80, P = 0.03 for the fourth quartile]. Comparable effects of vitamin A intake were observed irrespective of the location or histological type of gastric cancer. The HR for gastric cancer increased significantly only in subjects with a combination of high vitamin A intake (> 1,061 mu g RE/day) and Helicobacter pylori infection.
Our findings suggest that dietary vitamin A intake is clearly associated with the risk of gastric cancer in the general Japanese population.
A total of 2,467 community-dwelling Japanese subjects aged 40 years or older were followed up prospectively for 14 years. Dietary vitamin A intake was estimated using a semiquantitative food frequency method.
During the follow-up period, gastric cancer developed in 93 subjects. The age- and sex-adjusted incidence of gastric cancer rose progressively with increasing levels of dietary vitamin A intake: at 2.2, 3.0, 3.8, and 4.5 per 1,000 person-years for quartile groups defined by dietary vitamin A intake levels of < 639, 639-837, 838-1,061, and > 1,061 mu g retinol equivalents (RE)/day, respectively (P for trend < 0.01). The risk of gastric cancer was significantly higher in the fourth quartile than in the first one even after multivariate adjustment [hazard ratio (HR) = 1.47, 95% confidence interval (CI) = 0.70-3.09, P = 0.30 for the second quartile; HR = 1.85, 95% CI = 0.82-4.18, P = 0.14 for the third quartile; HR = 2.96, 95% CI = 1.12-7.80, P = 0.03 for the fourth quartile]. Comparable effects of vitamin A intake were observed irrespective of the location or histological type of gastric cancer. The HR for gastric cancer increased significantly only in subjects with a combination of high vitamin A intake (> 1,061 mu g RE/day) and Helicobacter pylori infection.
Our findings suggest that dietary vitamin A intake is clearly associated with the risk of gastric cancer in the general Japanese population.
- リンク情報
- ID情報
-
- DOI : 10.1007/s10120-011-0092-7
- ISSN : 1436-3291
- eISSN : 1436-3305
- PubMed ID : 21948483
- Web of Science ID : WOS:000303022500009