論文

査読有り
2003年

Bioinformatics Research on Inter-racial Difference in Drug Metabolism II. Analysis on Relationship between Enzyme Activities of CYP2D6 and CYP2C19 and their Relevant Genotypes

Drug Metabolism and Pharmacokinetics
  • Takako Shimizu
  • Shizuyo Yamaguchi
  • Munehiro Hashimoto
  • Yoshitaka Aida
  • Akira Ohashi
  • Naoki Ozawa
  • Hirohide Ochiai
  • Fredrik Asell
  • Yoshiya Yokono
  • Yoshiharu Kikuchi
  • Masashi Nitta
  • Yoshimasa Hama
  • Katsuhiko Taki
  • Kotoko Nakata
  • 全て表示

18
1
開始ページ
71
終了ページ
78
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2133/dmpk.18.71

The enzyme activities of CYP2D6 and CYP2C19 show a genetic polymorphism, and the frequency of poor metabolizers (PMs) on these enzymes depends on races. We have analyzed frequencies of mutant alleles and PMs based on the published data in previous study (Shimizu, T. etal.: Bioinformatics research on inter-racial difference in drug metabolism, I. Analysis on frequencies of mutant alleles and poor metabolizers on CYP2D6 and CYP2C19.). The study shows that there were racial differences in the frequencies of each mutant allele and PMs. In the present study, the correlation between genotypes and drug-metabolizing enzyme activities was investigated. The result showed that enzyme activities varied according to the genotypes of subjects even in the same race. On the other hand, if subjects had the same genotypes, almost no racial differences were observed in drug-metabolizing enzyme activities. From these results, it was supposed that the racial differences in activities of these enzymes could be explained by the differences in distribution of genotypes. It would be possible to explain the racial differences in drug-metabolizing enzyme activities based on the differences on individual pharmacogenetic background information, not merely by comparison of frameworks such as races and nations. © 2003, The Japanese Society for the Study of Xenobiotics. All rights reserved.

リンク情報
DOI
https://doi.org/10.2133/dmpk.18.71
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15618720
ID情報
  • DOI : 10.2133/dmpk.18.71
  • ISSN : 1880-0920
  • ISSN : 1347-4367
  • PubMed ID : 15618720
  • SCOPUS ID : 84992658158

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