論文

査読有り 国際誌
2019年

Metabolic Biomarkers in Nematode C. elegans During Aging.

Advances in experimental medicine and biology
  • Sumino Yanase
  • ,
  • Takamasa Ishii
  • ,
  • Kayo Yasuda
  • ,
  • Naoaki Ishii

1134
開始ページ
163
終了ページ
175
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/978-3-030-12668-1_9

Changes in energy metabolism occur not only in diseases such as cancer but also in the normal development and aging processes of various organisms. These metabolic changes result to lead to imbalances in energy metabolism related to cellular and tissue homeostasis. In the model organism C. elegans, which is used to study aging, an imbalance in age-related energy metabolism exists between mitochondrial oxidative phosphorylation and aerobic glycolysis. Cellular lactate and pyruvate are key intermediates in intracellular energy metabolic pathways and can indicate age-related imbalances in energy metabolism. Thus, the cellular lactate/pyruvate ratio can be monitored as a biomarker during aging. Moreover, recent studies have proposed a candidate novel biomarker for aging and age-related declines in the nematode C. elegans.

リンク情報
DOI
https://doi.org/10.1007/978-3-030-12668-1_9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30919337

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