2020年4月
Characterization of middle-molecule introduction into cells using mm-scale discharge in saline
Japanese Journal of Applied Physics
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- 巻
- 59
- 号
- 4
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.35848/1347-4065/ab7d7e
While gas-phase atmospheric pressure plasma (APP) is a promising technology for highly-efficient and minimally-invasive gene/drug (molecule) introduction, the reduction of external gas supply and the expansion of the effective treatment area in biological fluids for in vivo treatment are still challenging. We developed a device for mm-scale plasma generation in saline without working gas supply and demonstrated the local introduction of YOYO-1 molecule (molecular weight : 1271) into cultured cells using the device. Unlike the conventional APP accounting for chemical stimuli with reactive species, plasma-induced mechanical stimulus was indicated as one of key factor(s) in the molecule introduction.
- リンク情報
- ID情報
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- DOI : 10.35848/1347-4065/ab7d7e
- ISSN : 0021-4922
- eISSN : 1347-4065
- SCOPUS ID : 85083321894