2020年5月
Fibulin-7 C-terminal fragment and its active synthetic peptide suppress choroidal and retinal neovascularization.
Microvascular research
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- 巻
- 129
- 号
- 開始ページ
- 103986
- 終了ページ
- 103986
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.mvr.2020.103986
Wet age-related macular degeneration (AMD) and diabetic retinopathy are the leading causes of blindness through increased angiogenesis. Although VEGF-neutralizing proteins provide benefit, inconsistent responses indicate a need for new therapies. We previously identified the Fibulin-7 C-terminal fragment (Fbln7-C) as an angiogenesis inhibitor in vitro. Here we show that Fbln7-C inhibits neovascularization in vivo, in both a model of wet AMD involving choroidal neovascularization (CNV) and diabetic retinopathy involving oxygen-induced ischemic retinopathy. Furthermore, a short peptide sequence from Fbln7-C is responsible for the anti-angiogenic properties of Fbln7-C. Our work suggests Fbln7-C as a therapeutic candidate for wet AMD and ischemic retinopathy.
- リンク情報
- ID情報
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- DOI : 10.1016/j.mvr.2020.103986
- PubMed ID : 32017943