Kiyomi Ito

Profile Information

Affiliation: Faculty of Pharmacy Department of Pharmaceutical Sciences, Musashino University

Degree: 学士(東京大学)
修士(東京大学大学院)
博士(東京大学大学院)

J-GLOBAL ID: 201701005734726500
researchmap Member ID: B000271031

Research Interests

薬物動態・代謝学

Research Areas

Life sciences / Clinical pharmacy /

Research History

Apr, 2010 - Present

of Pharmaceutical Sciences, Graduate School, Musashino University
Apr, 2009 - Present

Faculty of Pharmacy, Department of Pharmaceutical Sciences, Musashino University
Apr, 2009 - Present

of Pharmaceutical Sciences, Graduate School, Musashino University
Apr, 2007 - Mar, 2009

Associate Professor
Sep, 2003 - Mar, 2007

Associate Professor
Sep, 2001 - Aug, 2003

Research Assistant
Dec, 1997 - Aug, 2003

Lecturer
Apr, 1996 - Nov, 1997

Research Assistant
Apr, 1991 - Mar, 1996

Research Assistant

Education

Apr, 1989 - Mar, 1991

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
Apr, 1987 - Mar, 1989

Faculty of Pharmaceutical Science, The University of Tokyo
Apr, 1982 - Mar, 1985

立教女学院高等学校

Awards

Papers

173

Physiologically based pharmacokinetic model analysis of the inhibitory effect of vonoprazan on the metabolic activation of proguanil

Kenjiro Okubo, Toshiyuki Kudo, Sae Yoshihara, Yu Nakabayashi, Kana Nakauchi, Akimi Tanaka, Moe Saito, Ayumi Tsujisawa, Hitomi Goda, Yoshiaki Yamagishi …

Drug Metabolism and Pharmacokinetics, 54 100537-100537, Feb, 2024
Quantitative Consideration of Clinical Increases in Serum Creatinine Caused by Renal Transporter Inhibition.

Tomohisa Nakada, Toshiyuki Kudo, Kiyomi Ito

Drug metabolism and disposition: the biological fate of chemicals, Mar 1, 2023
Caffeine consumption as a risk factor for childhood and adolescence migraine.

Toshiyuki Hikita, Hitomi Goda, Yasuko Ogawa, Toshiyuki Kudo, Kiyomi Ito

Pediatrics international : official journal of the Japan Pediatric Society, 65(1) e15429, Jan, 2023
Classification of drugs for evaluating drug interaction in drug development and clinical management.

Kazuya Maeda, Akihiro Hisaka, Kiyomi Ito, Yoshiyuki Ohno, Akihiro Ishiguro, Reiko Sato, Naomi Nagai

Drug metabolism and pharmacokinetics, 41 100414-100414, Dec, 2021
Pharmacokinetics and safety of rilpivirine in healthy Japanese subjects and exploration of ethnic sensitivity of rilpivirine pharmacokinetics with physiologically based pharmacokinetic model approach.

Kentaro Ohta, Nobuko Matsushima, Hiromi Tanii, Herta Crauwels, Toshiyuki Kudo, Kiyomi Ito

Drug metabolism and pharmacokinetics, 41 100422-100422, Dec, 2021
Gastroprotective Effect of Enteral Nutrition Formula in Mice Injected Subcutaneously with Indomethacin.

Yoshiaki Yamagishi, Rei Saiki, Takeshi Yoshimi, Toshiyuki Kudo, Kiyomi Ito

Nutrients, 13(9), Sep 21, 2021
Pharmacokinetics of CuGTSM, a Novel Drug Candidate, in a Mouse Model of Menkes Disease

Yoshiaki Yamagishi, Toshiyuki Kudo, Masafumi Oyumi, Yusuke Sakamoto, Kazuki Takahashi, Taiki Akashi, Shohei Kobayashi, Takeaki Kawakami, Hitomi Goda, Yasuhiro Sato …

Pharmaceutical Research, 38(8) 1335-1344, Aug, 2021 Peer-reviewedLast authorCorresponding author
In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization

Keiichi Morita, Motohiro Kato, Toshiyuki Kudo, Kiyomi Ito

Xenobiotica, 50(9) 1064-1075, Sep 1, 2020 Peer-reviewedLast authorCorresponding author
Chorea-like symptoms and high blood concentration of ceftriaxone in a patient undergoing hemodialysis: A case report

Yoshiaki Yokoyama, Naoto Hosokawa, Toshiyuki Kudo, Hitomi Goda, Kiyomi Ito, Masanori Suzuki, Ryohkan Funakoshi

Journal of Infection and Chemotherapy, 26(3) 285-288, Mar, 2020 Peer-reviewed
Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice

Takeshi Yoshimi, Yoshiaki Yamagishi, Issei Kanegawa, Megumi Suda, Rei Saiki, Ken-ichiro Tanaka, Hitomi Goda, Toshiyuki Kudo, Kiyomi Ito

Nutrients, 11(12) 3058-3058, Dec 14, 2019 Peer-reviewedLast authorCorresponding author
Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects

Tomohisa Nakada, Toshiyuki Kudo, Toshiyuki Kume, Hiroyuki Kusuhara, Kiyomi Ito

Drug Metabolism and Pharmacokinetics, 34(4) 233-238, Aug, 2019 Peer-reviewedLast authorCorresponding author
Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers

Ryohkan Funakoshi, Yukana Tomoda, Toshiyuki Kudo, Kenichi Furihata, Hiroyuki Kusuhara, Kiyomi Ito

British Journal of Clinical Pharmacology, 85(7) 1454-1463, Jul, 2019 Peer-reviewedLast authorCorresponding author
Chemoselective Demethylation of Methoxypyridine

Kosho Makino, Yumi Hasegawa, Takahide Inoue, Koji Araki, Hidetsugu Tabata, Tetsuta Oshitari, Kiyomi Ito, Hideaki Natsugari, Hideyo Takahashi

Synlett, 30(08) 951-954, May, 2019 Peer-reviewed
Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake

Ryo Fujino, Kenta Hashizume, Shinsuke Aoyama, Kazuya Maeda, Kiyomi Ito, Kota Toshimoto, Wooin Lee, Shin-ichi Ninomiya, Yuichi Sugiyama

European Journal of Pharmaceutical Sciences, 125 181-192, Dec, 2018 Peer-reviewed
How to Manage Drug Interactions in Clinical Settings (3)

Kenji Momo, Atsushi Yonezawa, Takuya Iwamoto, Yoshiyuki Ohno, Takeshi Kimura, Akihiro Hisaka, Kiyomi Ito

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 44(11) 559-567, Nov 10, 2018 Peer-reviewedLast authorCorresponding author
How to Manage Drug Interactions in Clinical Settings (2)

Takeshi Kimura, Takuya Iwamoto, Yoshiyuki Ohno, Akihiro Hisaka, Kenji Momo, Atsushi Yonezawa, Kiyomi Ito

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 44(11) 546-558, Nov 10, 2018 Peer-reviewedLast authorCorresponding author
How to Manage Drug Interactions in Clinical Settings (1)

Yoshiyuki Ohno, Akihiro Hisaka, Takuya Iwamoto, Takeshi Kimura, Kenji Momo, Atsushi Yonezawa, Kiyomi Ito

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 44(11) 537-545, Nov 10, 2018 Peer-reviewedLast authorCorresponding author
Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model

Tomohisa Nakada, Toshiyuki Kudo, Toshiyuki Kume, Hiroyuki Kusuhara, Kiyomi Ito

Drug Metabolism and Pharmacokinetics, 33(1) 103-110, Feb, 2018 Peer-reviewedLast authorCorresponding author
Estimation of the Contribution of CYP2C8 and CYP3A4 in Repaglinide Metabolism by Human Liver Microsomes Under Various Buffer Conditions

Toshiyuki Kudo, Hitomi Goda, Yuki Yokosuka, Ryo Tanaka, Seina Komatsu, Kiyomi Ito

Journal of Pharmaceutical Sciences, 106(9) 2847-2852, Sep, 2017 Peer-reviewedLast authorCorresponding author
Effect of buffer conditions on CYP2C8-mediated paclitaxel 6 alpha-hydroxylation and CYP3A4-mediated triazolam alpha- and 4-hydroxylation by human liver microsomes

Toshiyuki Kudo, Yuya Ozaki, Tomomi Kusano, Eri Hotta, Yuka Oya, Seina Komatsu, Hitomi Goda, Kiyomi Ito

XENOBIOTICA, 46(3) 241-246, Mar, 2016 Peer-reviewed

Misc.

医薬品添付文書におけるシトクロムP450及びトランスポーターを介する薬物相互作用に関する記載

鈴木浩史, 岡田章, 神谷春花, 内村考伸, 伊藤清美, 樋坂章博, 前田和哉, 豊島聰, 永井尚美

日本薬学会年会要旨集, 139年会(4) 176-176, Mar, 2019
CYP3A4活性に及ぼすvonoprazanおよびそのN-脱メチル体の影響

田中亜希実, 中林勇, 中内佳奈, 合田ひとみ, 舟越亮寛, 舟越亮寛, 牧野宏章, 高橋秀依, 山岸喜彰, 工藤敏之 …

日本薬学会年会要旨集(CD-ROM), 139th, 2019
vonoprazanおよびesomeprazoleとproguanilとの臨床相互作用試験

舟越亮寛, 友田有加菜, 工藤敏之, 牧野宏章, 高橋秀依, 楠原洋之, 降旗謙一, 伊藤清美

臨床薬理, 49(Supplement), 2018
CYP2C19の活性に及ぼすesomeprazoleとvonoprazanの影響

中林勇, 吉原早映, 中内佳奈, 合田ひとみ, 舟越亮寛, 舟越亮寛, 山岸喜彰, 工藤敏之, 伊藤清美

臨床薬理, 49(Supplement), 2018
プログアニルの代謝に及ぼすエソメプラゾールおよびボノプラザンの影響

中内佳奈, 中林勇, 合田ひとみ, 舟越亮寛, 山岸喜彰, 工藤敏之, 伊藤清美

日本医療薬学会年会講演要旨集(Web), 28, 2018
EFFECT OF BUFFER CONDITIONS ON CYP2C8-MEDIATED 6 alpha-HYDROXYLATION OF PACLITAXEL BY HUMAN LIVER MICROSOMES

Toshiyuki Kudo, Yuya Ozaki, Eri Hotta, Aya Matsubara, Kiyomi Ito

DRUG METABOLISM REVIEWS, 47 193-194, Nov, 2015
Quantitative prediction of drug-drug interactions by PBPK model using the in vivo K-i values

Akiko Kobashi, Jose Martin Ciloy, Mayumi Matsushita, Kazuya Maeda, Kiyomi Ito

DRUG METABOLISM REVIEWS, 47 113-113, Nov, 2015
P0332-22-AM ヒト肝細胞におけるシトクロムP450のmRNA発現に及ぼすメトロニダゾールおよびチニダゾールの影響(薬物相互作用,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

工藤敏之, 木林英彦, 遠藤由実子, 谷津雅美, 伊藤清美

日本医療薬学会年会講演要旨集, 25 321-321, Oct 23, 2015
Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes

Toshiyuki Kudo, Akihiro Hisaka, Yuchi Sugiyama, Kiyomi Ito

FASEB JOURNAL, 28(1), Apr, 2014
ANALYSIS OF THE GLIBENCLAMIDE CONCENTRATION INCREASE BY CLARITHROMYCIN BASED ON THE INHIBITION OF HEPATIC UPTAKE TRANSPORTER AND METABOLIC ENZYMES USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL

Toshiyuki Kudo, Akihiro Hisaka, Yuichi Sugiyama, Kiyomi Ito

DRUG METABOLISM REVIEWS, 44 73-74, 2012
Brassicasterolによるラット膀胱発癌抑制メカニズムの解明

小野哲也, 星野心広, 工藤敏之, 五十嵐信智, 伊藤清美, 落合和, 谷澤康玄, 杉山清

日本薬学会年会要旨集, 130th(4), 2010
簡易懸濁法におけるグラマリール細粒およびポンタールカプセルの主薬溶出性の検討

飯田純一, 北川佳奈子, 柚原亜美, 五十嵐信智, 伊藤清美, 杉山清

薬剤学: 生命とくすり, 69(Suppl.) 215-215, Apr, 2009
EFFECT OF YOKUKANSAN ON THE CYTOCHROME P450

Yoshizawa Mariko, Ichisawa Saori, Ikarashi Nobutomo, Ito Kiyomi, Ochiai Wataru, Watanabe Junko, Kanitani Masanao, Kase Yoshio, Sugiyama Kiyoshi

Abstracts of JSSX meeting, 24 255-255, 2009
EFFECT OF HYDROCOTARNINE ON THE CYP AND UGT EXPRESSION IN THE MOUSE LIVER

Ikarashi Nobutomo, Suto Satoshi, Hotta Asano, Ito Kiyomi, Ochiai Wataru, Sugiyama Kiyoshi

Abstracts of JSSX meeting, 24 268-268, 2009
DISPOSITION OF A NEW TAMIBAROTENE PRODRUG IN MICE

Ochiai Wataru, Sugitani Megumi, Abe Rieko, Ikarashi Nobutomo, Ito Kiyomi, Muratake Hideaki, Shudo Koichi, Sugiyama Kiyoshi

Abstracts of JSSX meeting, 24 310-310, 2009
ブラジカステロールによるラット膀胱発癌抑制メカニズムの解明

小野哲也, 星野心広, 工藤敏之, 五十嵐信智, 伊藤清美, 落合和, 谷澤康玄, 杉山清

生化学, 2009
21D-11 抑肝散とドネペジルの相互作用の検討(薬物相互作用,来るべき時代への道を拓く)

一澤砂央里, 五十嵐信智, 伊藤清美, 渡辺淳子, 森田敏美, 杉山清

日本医療薬学会年会講演要旨集, 18 270-270, Sep 1, 2008
20I-08 グラマリール^[○!R]細粒の経管投与における主薬回収率の検討(栄養管理・NST・薬物療法(高齢者),来るべき時代への道を拓く)

飯田純一, 矢野勝子, 五十嵐信智, 伊藤清美, 折井孝男, 杉山清

日本医療薬学会年会講演要旨集, 18 262-262, Sep 1, 2008
20I-07 経管投与における酸化マグネシウム併用時のアスピリンの安定性の検討(栄養管理・NST・薬物療法(高齢者),来るべき時代への道を拓く)

清水幸雄, 柚原亜美, 飯田純一, 五十嵐信智, 伊藤清美, 矢野勝子, 折井孝男, 杉山清

日本医療薬学会年会講演要旨集, 18 262-262, Sep 1, 2008
21-P3-544 電子カルテを用いた大学院生の病院実習(薬学教育(実務実習),来るべき時代への道を拓く)

久保田祐, 五十嵐信智, 伊藤清美, 杉山清, 澁谷文則

日本医療薬学会年会講演要旨集, 18 465-465, Sep 1, 2008

Books and Other Publications

医療薬学・臨床薬学

日本薬学会 (Role: Joint author)

東京化学同人, Oct, 2020 (ISBN: 9784807917235)
医療現場のための薬物相互作用リテラシー

大野, 能之, 樋坂, 章博 (Role: Joint author)

南山堂, Aug, 2019 (ISBN: 9784525776015)
最新薬剤学

尾関, 哲也, 井上, 勝央, 林, 正弘 (Role: Joint author)

廣川書店, Apr, 2018 (ISBN: 9784567480277)
生物薬剤学

西田, 孝洋, 伊藤, 清美, 井上, 勝央, 川上, 茂(薬学), 芝田, 信人, 永井, 純也 (Role: Joint author)

朝倉書店, Apr, 2018 (ISBN: 9784254362671)
臨床薬理学

日本臨床薬理学会, 小林, 真一, 長谷川, 純一(医学), 藤村, 昭夫, 渡邉, 裕司 (Role: Joint author)

医学書院, Nov, 2017 (ISBN: 9784260028738)
糖尿病の薬学管理必携 : 糖尿病薬物療法認定薬剤師ガイドブック

日本くすりと糖尿病学会, 清野, 裕, 杉山, 雄一, 門脇, 孝, 南條, 輝志男 (Role: Joint author)

じほう, Nov, 2017 (ISBN: 9784840749992)
パートナー薬剤学

原島, 秀吉, 伊藤, 智夫, 寺田, 勝英 (Role: Joint author)

南江堂, Mar, 2017 (ISBN: 9784524403370)

Research Projects

新規メンケス病治療薬創製を目指した銅錯体の体内動態および薬効の検討

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

工藤敏之, 高橋秀依, 深水啓朗, 山岸喜彰, 伊藤清美, 鈴木亮
Photoreaction of thioamides and its application to medicinal chemistry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Stereochemistry of N-S/N-N bond and its application to medicinal chemistry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Takahashi Hideyo
Elucidation of drug interaction mechanism by metronidazole and investigation of possibility of unknown interactions.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

KUDO Toshiyuki, ITO Kiyomi, HIROYA Kou
Alteration in the drug disposition in the mouse model of diabetes/obesity.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

ITO Kiyomi, SUGIYAMA Kiyoshi, IKARASHI Nobutomo, KUDO Toshiyuki
Effects of intestinal flora on cytochrome P450 and transporter

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

SUGIYAMA Kiyoshi, ITO Kiyomi, IKARASHI Nobutomo
小腸および肝臓における薬物間相互作用の定量的予測

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2004 - 2005

伊藤清美
脂肪組織からのアディポサイトカイン産生・分泌に及ぼす漢方薬の影響

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2004 - 2005

杉山清, 伊藤清美
薬物代謝阻害に基づく薬物間相互作用の定量的予測-阻害様式を考慮した予測方法の確立をめざして-

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1999 - 2000

伊藤清美
Analysis of the factors governing the elimination route of therapeutic agents

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

SUGIYAMA Yuichi, KUSUHARA Hiroyuki, KATO Yukio, SUZUKI Hiroshi, ITO Kiyomi
In vitro実験によるin vivo薬物間相互作用の予測ーレセプター結合占有理論に基づく薬効予測法の開発ー

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1997 - 1998

伊藤清美
Analysis of molecular basis for the presence of interindividual difference in the biliary excretion of xenobiotics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1998

SUZUKI Hiroshi, ITO Kiyomi, KATO Yukio, SUGIYAMA Yuichi
Analysis of multiplicity and polymorphism of drug transporters expressed in the liver.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1998

SUGIYAMA Yuichi, KUME Kazuhiko, ITO Kiyomi, KATO Yukio, SUZUKI Hiroshi
Role of hepatic transporters in the detoxification

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1997 - 1997

SUGIYAMA Yuichi, COLE Susan P.C., KAPLOWITZ Neil, ITO Kiyomi, KATO Yukio, SUZUKI Hiroshi
薬剤性パーキンソニズムの構造活性相関論的予測-ドパミンレセプター結合占有率とカタレプシ-発現との関係からのアプローチ-

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1996 - 1996

伊藤清美
分子薬理学的手法を用いた抗不安薬の離脱症状発現機構の解明

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1994 - 1994

伊藤清美

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