論文

査読有り
2016年

Pitavastatin Exhibits Protective Effects on Podocytes Accompanied by BMP-7 Up-Regulation and Rho Suppression

PHARMACOLOGY
  • Makoto Ohigashi
  • ,
  • Nobuyoshi Imai
  • ,
  • Hiroe Toba
  • ,
  • Miyuki Kobara
  • ,
  • Tetsuo Nakata

97
5-6
開始ページ
265
終了ページ
276
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1159/000444397
出版者・発行元
KARGER

Background/Aims: Podocytes injury is involved in the development of diabetic nephropathy. This study was designed to confirm the reno- and podocyte-protective effects of pitavastatin in diabetic rats and clarify its mechanisms. Methods: Wistar rats were divided into 4 treatment groups: control, streptozotocin (STZ; 55 mg/kg)-induced diabetes, STZ with pitavastatin (10 mg/kg/day), and STZ with tempol (1 mmol/l). Results: STZ-induced diabetic rats exhibited increases in urinary protein excretion and plasma creatinine, and a decrease in creatinine clearance. Pitavastatin significantly improved these parameters without reducing cholesterol levels, whereas tempol did not. The treatment with STZ-enhanced renal fibrosis, mesangial proliferation, transforming growth factor (TGF)-beta, MCP-1 and suppressed Rho in association with decrement of bone morphogenetic protein (BMP)-7 expression in renal cortex. Moreover, STZ decreased podocyte related factors, podocin and nephrin, and BMP-7 in podocytes. Pitavastatin significantly ameliorated all these indices. On the other hand, improvement by tempol was found only in TGF-beta, MCP-1 and histological changes. Conclusion: Pitavastatin exhibited reno- and podocyte-protective effects accompanied by BMP-7 preservation and Rho suppression. (C) 2016 S. Karger AG, Basel

リンク情報
DOI
https://doi.org/10.1159/000444397
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26910564
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000372524800008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1159/000444397
  • ISSN : 0031-7012
  • eISSN : 1423-0313
  • PubMed ID : 26910564
  • Web of Science ID : WOS:000372524800008

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