Kohji ISHIHARA

Profile Information

Affiliation: Okayama University of Science

Degree: 修士（理学）(大阪大学大学院)
博士（工学）(岡山大学大学院)

Contact information: ishiharaous.ac.jp
J-GLOBAL ID: 200901008113510209
researchmap Member ID: 1000274244

External link: https://drive.google.com/file/d/1MNU3arXd3A7V2zE3CMtxjhEUiGKlGykb/view?usp=sharing

Research Interests

Research Areas

Research History

Apr, 2022 - Present

教授, 生命科学部生物科学科, 岡山理科大学
Apr, 2015 - Mar, 2025

Faculty of Science, Department of Life Science, Okayama University of Science
Apr, 2012 - Mar, 2015

岡山理科大学大学院理学研究科材質理学専攻（博士課程）・准教授
Apr, 2011 - Mar, 2015

岡山理科大学理学部臨床生命科学科准教授
Apr, 2005 - Mar, 2015

Faculty of Science, Department of Life Science, Okayama University of Science
Apr, 2008 - Apr, 2011

岡山理科大学大学院理学研究科臨床生命科学専攻（修士課程）・講師
Apr, 2004 - Mar, 2008

岡山理科大学理学部臨床生命科学科・講師
Apr, 1995 - Mar, 2004

京都教育大学教育学部理学科・文部教官助手
May, 2003 - Feb, 2004

平成１５年度文部科学省内地研究員

Awards

Jan, 2007

岡山リサーチパーク研究・展示発表会奨励賞, 岡山県産業振興財団

石原浩二
May, 2005

日本農芸化学会中四国支部奨励賞, 日本農芸化学会中四国支部

石原浩二
日本農芸化学会2013年度大会トピックス賞, NADP依存性ギ酸脱水素酵素の開発, 日本農芸化学会

ダイセル化学との共同受賞

Papers

Enzymatic Synthesis of Memantine (Memary) Oligosaccharides (Gluco-oligosaccharides) and their application as anti-dementia drugs that cross the Blood-Brain Barrier (BBB)

H. Hamada, K. Ishihara, K. Shimoda, A. Kuboki, Y. Kiriake, R. Hosoda

Int. J. Curr. Microbiol. App. Sic., 12(08) 1-6, Aug, 2023 Peer-reviewed
Enzymatic Synthesis of Resveratrol Oligosaccharides (Gluco-oligosaccharides) and their Enhanced Application as Antidementia Drugs that Cross the Blood-brain Barrier (BBB)

Hiroki Hamada, Kohji Ishihara, Kei Shimoda, Atsuhito Kuboki, Yuya Kiriake, Ryusuke Hosoda, Noriyuki Uchida

International Journal of Current Microbiology and Applied Sciences, 11(7) 260-266, Jul 20, 2022
Biocatalytic Preparation of Chiral Alcohols with Green Micro Algae: Bio-reduction of Carbonyl Compounds by Chlorogonium Strains as a Novel Biocatalyst

Ishihara K., Oka S., Hayashi Y., Kitagawa Y., Kondo Y., Shimoda K., Masuoka N., and Nakajima N.

Int. J. Curr. Microbiol. Appl. Sci., 11(4), Apr, 2022 Peer-reviewed
Cultivation of rice in the southern area of Okayama prefecture, Japan

NAKAJIMA Nobuyoshi, ISHIHARA Kohji

28(1) 157-162, Dec, 2021
Enzymatic Synthesis of alpha-Tocopherol Derivative Glycoside, Daidzein Glycoside, Daidzein Oligosaccharide, Resveratrol Oligosaccharide, and Curcumin Oligosaccharides and Their Anti-Allergic Activity and Neuroprotective Activity

Hiroki Hamada, Hatsuyuki Hamada, Kohji Ishihara, Atsuhito Kuboki, Takafumi Iwaki, Yuya Kiriake

NATURAL PRODUCT COMMUNICATIONS, 16(10), Oct, 2021 Peer-reviewed
Synthesis of Ester-Linked Paclitaxel-Glycoside Conjugate as a Water-Soluble Paclitaxel Derivative-Maltoside Modification of Paclitaxel through Ester-Linker (Ester-Spacer)

Hiroki Hamada, Hatsuyuki Hamada, Kei Shimoda, Tadakatsu Mandai, Kohji Ishihara, Yuya Kiriake, Atsuhito Kuboki

NATURAL PRODUCT COMMUNICATIONS, 16(9) 1-3, Sep, 2021 Peer-reviewed
Resveratrol Oligosaccharides (Gluco-Oligosaccharides) Effectively Inhibit SARS-CoV-2 Infection: Glycoside (Polysaccharide) Approach for Treatment of COVID-19

Hiroki Hamada, Hatsuyuki Hamada, Kei Shimoda, Atsuhito Kuboki, Takafumi Iwaki, Yuya Kiriake, Kohji Ishihara

NATURAL PRODUCT COMMUNICATIONS, 16(5) 1-3, May, 2021 Peer-reviewed
Synthesis of Ester-linked Paclitaxel-glycoside Conjugate and Its Drug Delivery System using Hybrid-bio-nanocapsules Targeted with Trastuzumab

Yuya Fujitaka, Hiroki Hamada, Hatsuyuki Hamada, Kohji Ishihara, Takafumi Iwaki, Kei Shimoda, Yuya Kiriake, Tomohiro Saikawa

Natural Product Communications, 16(1) 1-3, Jan, 2021 Peer-reviewed
保健食品クロレラ製剤：グロスミンの生体触媒としての応用

石原浩二,中島伸佳

岡山県立大学保健福祉学部紀要, 27(1) 77-81, Dec, 2020
食品素材などとしての「高機能化ポリフェノール誘導体」の酵素的合成システムの開発

中島伸佳,石原浩二

岡山県立大学保健福祉学部紀要, 27(1) 141-145, Dec, 2020
Screening for novel lipase from microorganisms: Search for lipase activity in basidiomycetes mainly on edible mushrooms

K. Ishihara, N. Kumazawa, N. Nakajima

26(1) 61-65, Dec, 2019 Peer-reviewed
Glycosylation of Piceid and Resveratroloside by Bioconversion with Phytolacca americana Glucosyltransferase Expressed in Escherichia coli

Kei Shimoda, Naoji Kubota, Shouta Okada, Shouta Doi, Daisuke Uesugi, Hatsuyuki Hamada, Hiroki Hamada, Atsuhito Kuboki, Takafumi Iwaki, Yuya Kiriake …

NATURAL PRODUCT COMMUNICATIONS, 14(7) 1-2, Jul, 2019 Peer-reviewed
Microbial Production of Chiral Hydroxy Esters and Their Analogues: Biocatalytic Reduction of Carbonyl Compounds by Actinobacteria, Agromyces and Gordonia Strains

K. Ishihara, N. Adachi, T. Mishima, C. Kuboki, A. Shuto, K. Okamoto, M. Inoue, H. Hamada, D. Uesugi, N. Masuoka …

Advances in Enzyme Research, 7 15-25, Jul, 2019 Peer-reviewed
Chemo-enzymatic Synthesis of Ester-Linked Docetaxel-Glycoside Conjugate and its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab and Cetuximab

Yuya Fujitaka, Hiroki Hamada, Hatsuyuki Hamada, Noriyoshi Masuoka, Kei Shimoda, Daisuke Uesugi, Takafumi Iwaki, Atsuhito Kuboki, Kohji Ishihara, Yuya Kiriake

Natural Product Communications, 14(6) 1-3, Jun, 2019 Peer-reviewed
Biocatalytic Reduction of Carbonyl Compounds by Actinobacteria from Two Genera of the Micromonosporaceae Family: Actinoplanes and Dactylosporangium

K. Ishihara, K. Morita, Y. Nishimori, S. Okamoto, T. Hiramatsu, A. Okawa, D. Uesugi, M. Yanagi, H. Hamada, N. Masuoka …

International Journal of Current Microbiology and Applied Sciences, 8(4) 920-931, Apr, 2019 Peer-reviewed
Re-Investigation of the physiological functions of the new supplement produces mainly from the plant-based extracts fermented by lactic acid bacteria and yeast

Nobuyoshi NAKAJIMA and Kohji ISHIHARA

25(1) 19-25, Dec, 2018 Peer-reviewed
Ferulic Acid, Methyl Ferulate, and Ferulic Acid Glucopyranosyl Ester Isolated from Cultured Cells of Phytolacca americana

Shimoda Kei, Kubota Naoji, Hamada Hiroki, Doi Shouta, Ishihara Kohji, Hamada Hatsuyuki, Fujitaka Yuya, Ono Tsubasa, Araki Minami

NATURAL PRODUCT COMMUNICATIONS, 13(1) 67-68, Jan, 2018 Peer-reviewed
Effect of Aspergillus awamori on Alloxian-induced Mouse Hyperglycemia

S. Masuda, Y. Okachi, T. Hirago, K. Matsuoka, R. Miura, S. Miyoshi, T. Murakami, J. Inoue, K. Ishihara, N. Masuoka

Journal of Food Research, 6(6) 29-34, Oct, 2017 Peer-reviewed
Microbial Preparation of Chiral Alcohols: Stereoselective Reduction of Carbonyl Compounds using Two Genera of the Streptosporangiaceae Family - Streptosporangium and Nonomuraea

K. Ishihara, A. Chiba, K. Onishi, A. Okawa, Y. Mizote, D. Uesugi, N. Masuoka, N. Nakajima, H. Hamada

International Journal of Current Microbiology and Applied Sciences, 6(8) 707-717, Aug, 2017 Peer-reviewed
Glycosylation and Methylation of Quercetin and Myricetin by Cultured Cells of Phytolacca americana

Yuya Fujitaka, Kei Shimoda, Naoji Kubota, Minami Araki, Tatsuya Onishi, Noriyuki Nakayama, Kohji Ishihara, Masato Tanigawa, Hatsuyuki Hamada, Hiroki Hamada

NATURAL PRODUCT COMMUNICATIONS, 12(4) 523-524, Apr, 2017 Peer-reviewed

Misc.

Effect of hydrogen peroxide on normal and acatalasemic mouse erythrocytes.

Noriyoshi Masuoka, Ayumi Zukeran, Kazunori Takemoto, Da-Hong Wang, Kohji Ishihara

Toxicology reports, 7 282-287, 2020
Effect of fermented-burdock on alloxan-induced mouse diabetes

Doi Wakana, Takemoto Kazunori, Ansai Kazuyuki, Ishihara Kohji, Murakami Takayuki, Inoue Junji, Oda Sen-ichi, Masuoka Noriyoshi

The bulletin of the Okayama University of Science. A, Natural science, 49 11-17, 2013
polyphenol compounds in grapes cultured in Okayama Prefecture

Msuoks Noriyoshi, Kuroda Kouhei, Okada Takehiko, Hashimoto Maki, Ishihara Kohji

The bulletin of the Okayama University of Science. A, Natural science, 46 1-7, 2010
Studies on the plant-based extract fermented by lactic acid bacteria and yeast

Trace nutrients research, 26 96-104, 2009
Studies on bioactive compounds in okara for developing a new food stuff

Kasahara Mitsugu, Kmada Mai, Kodama Hiroyuki, Hayashi Yuriko, Ishihara kohji, Masuoka Noriyoshi

The bulletin of the Okayama University of Science. A, Natural science, 45 5-10, 2009
The effect of juice made from Pione grape-skin extract

Noriyoshi "Masuoka, Da-Hong Wang, Michiko Kogashiwa, Koichi Miyashita, Terumasa Nakaie, Kohji Ishihara, Hiroki" Hamada

43 33-39, 2007
Enzymatic oxidation of 1,4- and 1,8-cineole using plant cultured cells of Catharanthus roseits

H Hamada, K Ishihara, N Nakajima, H Hamada, HJ Williams, AI Scott

LETTERS IN ORGANIC CHEMISTRY, 1(2) 171-172, Apr, 2004
Stereoselective biotransformation of limonene and limonene oxide by cyanobacterium, Synechococcus sp PCC 7942

H Hamada, Y Kondo, K Ishihara, N Nakajima, H Hamada, R Kurihara, T Hirata

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 96(6) 581-584, Dec, 2003
Earthworm-serine protease: Characterization, molecular cloning, and application of the catalytic functions

Nobuyoshi Nakajima, Manabu Sugimoto, Kohji Ishihara

Journal of Molecular Catalysis B: Enzymatic, 23(2-6) 191-212, Sep 1, 2003
Stereoselective reduction of keto esters: thermophilic bacteria and microalgae as new biocatalysts

K Ishihara, H Yamaguchi, N Nakajima

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 23(2-6) 171-189, Sep, 2003
Biotransformation using plant cultured cells

K Ishihara, H Hamada, T Hirata, N Nakajima

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 23(2-6) 145-170, Sep, 2003
エコシステムを利用した瀬戸内海沿岸の海洋環境汚染物質の除去・回収法の開発--環境ホルモン関連物質を中心として

石原浩二, 中島伸佳, 内村祐之

助成研究報告集, 2001 245-257, 2001
High production of beta-thujaplicin with Thuja dolabrata var. hondai cells in a semi-continuous culture system

K Sanada, A Kawaguchi, T Furuya, K Ishihara, N Nakajima, H Hamada

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 11(1) 59-61, Nov, 2000
海洋性微細藻類を用いる内分泌攪乱物質(環境ホルモン)の機能改変と海洋汚染物質の除去に関する研究

中島伸佳, 石原浩二, 内村祐之

助成研究報告集, 2000 317-326, 2000
食品添加物としての、天然植物色素の酵素的安定化と、抗酸化性を中心としたそれらの付随的生理機能の解明

中島伸佳, 石原浩二, 中村薫

食に関する助成研究調査報告書, (13) 15-21, 2000
Multi-enzymatic glucosylation using Eucalyptus UDP-glucosyltransferase coupled UDPglucose-fermentation by bakers' yeast

N Nakajima, K Ishihara, H Hamada, S Yamane, K Nakamura, T Furuya

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 63(5) 934-936, May, 1999
Further Characterization of Earthworm Serine Proteases : Cleavage Specificity Against Peptide Substrates and on Autolysis

Nobuyoshi NAKAJIMA, Manabu SUGIMOTO, Kohji ISHIHARA, Kaoru NAKAMURA, Hiroki HAMADA

Biosci. Biotechnol. Biochem., 63(11) 2031-2033, 1999
Lipase-Catalyzed Synthesis of Arbutin Cinnamate in Organic Solvent and Application of Transesterification to Stabilizel Plant Pigments(jointly worked)

Nobuyoshi NAKAJIMA, Kohji ISHIHARA, Shingo MATSUMURA, Hiroki HAMADA, Kaoru NAKAMURA, Tsutomu FURUYA

Biosci. Biotech. Biochem, 61(11) 1926-1928, 1997
Differences in Protein Structure and Similarities in Catalytic Function of Two L-Selective Carbonyl Reductases from Bakers' Yeast. (jointly worked)

Nobuyoshi Nakajima, Kohji Ishihara, Shin-Ichi Kondo, Sadao Tsuboi, Masanori Utaka, Kaoru Nakamura

Biosci. Biotech. Biochem., 58(11) 2080-2081, 1994

Books and Other Publications

Handbook of Proteolytic Enzymes 2nd Edn.

(Role: Joint author)

Elsevier, Oct, 2004

Presentations

Biocatalytic Stereoselective Reduction of Carbonyl Compounds by actinobacteria from the Streptomycetaceae, Streptosporangiacae, and Micromonosporaceae families

Ishihara, K., Kondo, A., Kashima, H., Yoshimura, T., Chiba, A., Ohnishi, K., Morita, K., Hiramatsu, T., Masuoka, N., Hamada, H., and Nakajima, N.

Pacifichem 2021, Dec 16, 2021
Preparation of chiral alcohols using actinobacteria: Biocatalyst activity of marine-derived actinomycetes

K. Ishihara, G. Hori, N. Masuoka, N. Nakajima, H. Hamada

Pacifichem2015, Dec, 2015
Biocatalyst activity of entomogenous fungi: Stereoselective reduction of carbonyl compounds using tochukaso and related species

K. Ishihara, G. Hori, N. Masuoka, H. Hamada, N. Nakajima

Pacifichem2015, Dec, 2015

Teaching Experience

Apr, 2022 - Present

生化学
Apr, 2022 - Present

生命科学のための化学
Sep, 2021 - Present

Food Biotechnology (Okayama University of Science)
専門英語ⅡＡ (岡山理科大学)
専門英語ⅡＢ (岡山理科大学)
卒業研究Ⅱ (岡山理科大学)
専門英語ⅠＡ (臨床) (岡山理科大学)
生命科学のための化学（BB後とBC） (岡山理科大学)
生物化学実験Ⅰ 【水３金３】 (岡山理科大学)
専門英語ⅡＡ (臨床) (岡山理科大学)
専門英語ⅡＢ (臨床) (岡山理科大学)
専門英語ⅠＢ (臨床) (岡山理科大学)
基礎栄養学【火1金1】 [FB11] (岡山理科大学)
特別研究《春学期最終評価》 (岡山理科大学)
専門英語ⅠＢ(臨床) (岡山理科大学)
卒業研究Ⅰ (岡山理科大学)
臨床医学特別研究 (岡山理科大学)
専門英語ⅠＡ(臨床) (岡山理科大学)
専門英語Ⅰ(再)(臨床) (岡山理科大学)
地球物性特別研究 (岡山理科大学)

Professional Memberships

Research Projects

食品製造工程で廃棄されるぶどう残渣から抽出した抗酸化作用のあるレスベラトロール（ポリフェノールの一種）を添加した新規飲料の開発

令和４年度エコプロダクツ製品化支援事業補助金（岡山県）代表：益岡典芳との共同研究, 津高果汁研究所, Aug, 2022 - Feb, 2023

石原浩二

Committee Memberships

May, 2021 - Mar, 2022

研究・社会連携推進委員会副委員長
Apr, 2020 - Mar, 2022

省エネルギー委員会学科代表委員
May, 2020 - Mar, 2021

研究・社会連携推進委員会学科代表委員
Apr, 2017 - Mar, 2021

研究・社会連携推進委員会学科代表委員
Apr, 2016 - Mar, 2020

教職・学芸員委員会学科代表委員
Apr, 2016 - Mar, 2017

学外連携推進委員学科代表委員
Apr, 2015 - Mar, 2016

学外連携推進委員会学科代表委員
Apr, 2014 - Mar, 2015

学外連携推進委員委員
Apr, 2013 - Mar, 2014

学外連携推進委員会副委員長
Apr, 2013 - Mar, 2014

教職・学芸員委員会委員
Apr, 2013 - Mar, 2014

教務委員
Apr, 2011 - Mar, 2012

省エネルギー委員会委員
Apr, 2011 - Mar, 2012

学外連携推進委員会委員
Apr, 2010 - Mar, 2011

省エネルギー委員会委員
Apr, 2010 - Mar, 2011

教職・学芸員委員会委員
Apr, 2010 - Mar, 2011

学外連携推進委員会委員
Apr, 2009 - Mar, 2010

学外連携推進委員会副委員
Apr, 2008 - Mar, 2009

学外連携推進委員会委員
Apr, 2004 - Mar, 2009

学科メールサーバ管理委員
Apr, 2007 - Mar, 2008

学外連携推進委員会副委員長

Industrial Property Rights

特開2005-218348 Method for Producing Optically Active Alpha-Hydroxy Amide

Profile Information

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Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

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Industrial Property Rights

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