Koichi Miyake

Profile Information

Affiliation: Nippon Medical School

Degree: 医学博士(日本医科大学)

Researcher number: 90267211
J-GLOBAL ID: 200901080629944844
researchmap Member ID: 5000100390

Research Interests

Gene Therapy, Hypophosphatasia

Research Areas

Research History

Feb, 2021 - Present

Professor, Department of Gene Therapy, Nippon Medical School
Apr, 2007 - Jan, 2021

Associate Professor, Department of Biochemistry and Molecular Biology, Nippon Medical School
Apr, 1999 - Mar, 2007

Associate Professor/Lecturer, Department of Biochemistry and Molecular Biology, Nippon Medical School
Feb, 2003 - Mar, 2005

Research Scientist, Molecular Medicine and Gene Therapy, Lund university
May, 1996 - Mar, 1999

Assistant professor, Department of Biochemistry and Molecular Biology, Nippon Medical School
Jun, 1994 - Apr, 1996

Acting assistant professor, Department of Biochemistry and Molecular Biology, Nippon Medical School
Jun, 1988 - May, 1990

The third department of internal medicine, Nippon Medical School

Education

Apr, 1990 - Mar, 1994

Nippon Medical School Graduate School
Apr, 1982 - Mar, 1988

Medical School, Nippon Medical School

Committee Memberships

- Present

厚生労働省厚生科学審議会遺伝子治療臨床研究に関する審査委員会委員
- Present

大阪大学第二特定認定再生医療等委員会委員
- Present

日本遺伝子細胞治療学会評議員

Awards

Papers

117

Gene Therapy for Hypophosphatasia: Current Management and Future

Tae Matsumoto, Sonoko Narisawa, José Luis Millán, Koichi Miyake

Genetically Modified Organisms [Working Title], Aug 9, 2024
Development of a new gene therapy drug as a treatment for hypophosphatasia

Koichi Miyake

Open Access Government, 39 44-45, Jul 10, 2023
Development of gene therapy for hypophosphatasia

Koichi Miyake

Impact, 2023 59-61, Apr 14, 2023
Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia.

Flavia Amadeu de Oliveira, Fatma F Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan

JBMR plus, 7(1) e10709, Jan, 2023
Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A.

Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Hidenori Suzuki, Takashi Shimada

Scientific reports, 11(1) 20513-20513, Oct 15, 2021
Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection.

Tae Matsumoto, Koichi Miyake, Noriko Miyake, Osamu Iijima, Kumi Adachi, Sonoko Narisawa, José Luis Millán, Hideo Orimo, Takashi Shimada

Molecular therapy. Methods & clinical development, 22 330-337, Sep 10, 2021
Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl-/- Mice.

Yuka Kinoshita, Fatma F Mohamed, Flavia Amadeu de Oliveira, Sonoko Narisawa, Koichi Miyake, Brian L Foster, José Luis Millán

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(9) 1835-1849, Sep, 2021
Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery

Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Yuko Katakai, Hiromi Hayashita-Kinoh, Chiaki Fujimoto, Shuhei Kameya, Hiroshi Takahashi, Takashi Okada

Journal of Nippon Medical School, 88(2) 103-108, Apr 24, 2021
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.

Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Katoh, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa …

Nature communications, 11(1) 5311-5311, Oct 20, 2020
TERT and TERC mutations detected in cryptic dyskeratosis congenita suppress telomerase activity.

Kazuki Terada, Koichi Miyake, Hiroki Yamaguchi, Noriko Miyake, Keiichiro Yamanaka, Seiji Kojima, Etsuro Ito, Koiti Inokuchi, Takashi Okada

International journal of laboratory hematology, 42(3) 316-321, Jun, 2020 Peer-reviewed
Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.

Haginiwa, Sho, Sadahiro, Taketaro, Kojima, Hidenori, Isomi, Mari, Tamura, Fumiya, Kurotsu, Shota, Tani, Hidenori, Muraoka, Naoto, Miyake, Noriko, Miyake, Koichi …

Biochemical and biophysical research communications, 513(4) 1041-1047, Jun, 2019 Peer-reviewed
Neutralizing antibody titer against AAV post AAV-mediated intravitreal injection in cynomolgus monkeys.

Masashi Yamazaki, Tsutomu Igarashi, Kazuhisa Takahashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Shuhei Kameya, Hiroshi Takahashi, Takashi Okada

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9), Jul, 2018
D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia

Ikuko Omori, Hiroki Yamaguchi, Koichi Miyake, Noriko Miyake, Tomoaki Kitano, Koiti Inokuchi

EXPERIMENTAL HEMATOLOGY, 52 56-64, Aug, 2017 Peer-reviewed
Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNF alpha Treatment

Hayato Tamai, Hiroki Yamaguchi, Koichi Miyake, Miyuki Takatori, Tomoaki Kitano, Satoshi Yamanaka, Syunsuke Yui, Keiko Fukunaga, Kazutaka Nakayama, Koiti Inokuchi

CANCER RESEARCH, 77(16) 4426-4433, Aug, 2017 Peer-reviewed
MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

Atsushi Sakai, Fumihito Saitow, Motoyo Maruyama, Noriko Miyake, Koichi Miyake, Takashi Shimada, Takashi Okada, Hidenori Suzuki

NATURE COMMUNICATIONS, 8 16079, Jul, 2017 Peer-reviewed
miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down regulation

Naomi Ito, Atsushi Sakai, Noriko Miyake, Motoyo Maruyama, Hirotoshi Iwasaki, Koichi Miyake, Takashi Okada, Atsuhiro Sakamoto, Hidenori Suzuki

BRITISH JOURNAL OF PHARMACOLOGY, 174(5) 386-395, Mar, 2017 Peer-reviewed
Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Osamu Iijima, Yoshiyuki Yamazaki, Yuko Katakai, Noriko Miyake, Shuhei Kameya …

MOLECULAR THERAPY, 25(1) 296-302, Jan, 2017 Peer-reviewed
Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation

Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Shuhei Kameya, Chiaki Fujimoto, Kenji Nakamoto, Hisatomo Takahashi, Toru Igarashi, Noriko Miyake, Osamu Iijima …

MOLECULAR VISION, 22 816-826, Jul, 2016 Peer-reviewed
Sensitivity of RCSD1-ABL1 Positive Acute Lymphoblastic Leukemia to TKIs Varies between Fusion sites in Ph-like Acute Lymphoblastic Leukemia

Tamai H, Yamaguchi H, Miyake K, Takatori M, Kitano T, Dan K, Inokuchi K

Inteernational Journal of Recent scientific Research, 7(3) 9729-9733, Mar, 2016
Leukemogenicity of RCSD1 and Sensitivity to TKIs Vary between Fusion sites in Phlike Acute Lymphoblastic Leukemia

Tamai H, Yamaguchi H, Miyake K, Takatori M, Kitano T, Dan K, Inokuchi K

International Journal of Recent scientific Research, 7(3) 9729-9733, Mar, 2016

Misc.

152

低ホスファターゼ症に対する新規治療薬(遺伝子治療薬:ARU-2801)の有効性と安全性の検討

松本多絵, 趙東威, 三宅紀子, 成澤園子, ミヤン・ホセ, 三宅弘一

日本小児科学会雑誌, 128(2) 272-272, Feb, 2024
研究者の最新動向低ホスファターゼ症に対する遺伝子治療

三宅弘一

Precision Medicine, 6(3) 226-230, Mar, 2023
低ホスファターゼ症に対する新規治療法(遺伝子治療薬)の開発

三宅弘一

BIO Clinica, 38(1) 87-91, Jan, 2023
Development of a novel gene therapy drug (ARU-2801) for Hypophosphatasia

三宅弘一

月刊Precision Medicine, 5(10), 2022
Development of gene therapy drug (ARU-2801) for Hypophosphatasia

三宅弘一

Bio Clinica, 37(6), 2022
AAVベクターの硝子体投与における内境界膜剥離併用硝子体手術とサル網膜への遺伝子導入改善効果と安全性の検討

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 三宅紀子, 亀谷修平, 島田隆, 岡田尚巳 …

眼科臨床紀要, 11(7) 554-554, Jul, 2018
アデノ随伴ウイルスベクターによる遺伝子治療と内境界膜剥離

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 三宅紀子, 亀谷修平, 島田隆, 岡田尚巳 …

日本眼科学会雑誌, 122(3) 251-252, Mar, 2018
サルに対するAAVベクター硝子体投与による血中抗体価の検討

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 喜納裕美, 三宅紀子, 亀谷修平, 島田隆 …

日本眼科学会雑誌, 122(臨増) 260-260, Mar, 2018
Efficient Transduction of Inner Retina by Surgical Internal Limiting Membrane (ILM) Peeling Before Intravitreal AAV Vector Injection in Cynomolgus Monkeys

Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Osamu Iijima, Yoshiyuki Yamazaki, Noriko Miyake, Shuhei Kameya, Takashi Shimada …

MOLECULAR THERAPY, 25(5) 111-111, May, 2017
Why Are scAAV9 Vectors Able to Pass Through the BBB but Not ssAAV9?; The Difference Between the ssAAV9 and scAAV9 Vector in Transduction of CNS by Intravenous Injection

Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada

MOLECULAR THERAPY, 25(5) 320-321, May, 2017
遺伝子治療による網膜神経節細胞保護治療の現状と問題点

五十嵐勉, 五十嵐勉, 三宅弘一, 高橋和久, 高橋和久, 中元兼二, 岡田尚巳, 高橋浩

日本緑内障学会抄録集, 28th, 2017
サルに対する内境界膜剥離併用硝子体手術による遺伝子導入法の開発

高橋和久, 高橋和久, 五十嵐勉, 五十嵐勉, 三宅弘一, 小林舞香, 矢口智恵美, 飯島修, 山崎吉之, 亀谷修平 …

日本緑内障学会抄録集, 28th, 2017
New innovations for ocular gene therapy

五十嵐勉, 五十嵐勉, 三宅弘一, 小林舞香, 小林舞香, 高橋和久, 高橋和久, 中元兼二, 岡田尚巳, 高橋浩

日本医科大学医学会雑誌, 13(2) 88-96, 2017
Amlexanox As a Possible Breakthrough Drug for MLL/AF4 Positive Acute Lymphoblastic Leukemia

Hayato Tamai, Hiroki Yamaguchi, Koichi Miyake, Miyuki Takatori, Tomoaki Kitano, Syunsuke Yui, Keiko Fukunaga, Kazutaka Nakayama, Koiti Inokuchi

BLOOD, 128(22), Dec, 2016
Tyrosine-mutated AAV2 (Y730, 500, 444F) mediated BDNF rescued inner retina in rat retinal ischemic injury model

M. Kobayashi, T. Igarashi, K. Miyake, N. Miyake, K. Nakamoto, Y. Hirai, H. Takahashi, T. Okada

HUMAN GENE THERAPY, 27(11) A122-A123, Nov, 2016
仲間と、そして市民としてのSP参加で学ぶ新入生オリエンテーションTBL(第2報)

藤倉輝道, 松本尚, 三宅弘一, 樫村正美

医学教育, 47(Suppl.) 187-187, Jul, 2016
神経障害性疼痛におけるmiR‐17‐92クラスターによるカリウムチャネルの調節

坂井敦, 丸山基世, 丸山基世, 三宅紀子, 齋藤文仁, 三宅弘一, 島田隆, 岡田尚巳, 鈴木秀典

Pain Research, 31(2) 86, Jun 24, 2016
Successful Treatment of Neonatal Metachromatic Leukodystrophy Model Mice by Low Dose of Self-Complementary AAV Type9 Vector Expressing ASA

Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada

MOLECULAR THERAPY, 24 S63-S63, May, 2016
BDNFを発現するチロシン変異AAV2を用いた網膜虚血モデルにおける神経保護効果

五十嵐勉, 三宅弘一, 小林舞香, 高橋和久, 三宅紀子, 中元兼二, 岡田尚巳, 高橋浩

眼科臨床紀要, 8(10) 772-772, Oct, 2015
網膜一過性虚血モデルにおけるチロシン変異AAV2ベクター由来BDNFの神経保護効果

五十嵐勉, 三宅弘一, 中元兼二, 小林舞香, 亀谷修平, 三宅紀子, 飯島脩, 岡田尚巳, 島田隆, 高橋浩

日本緑内障学会抄録集, 26回 114-114, Sep, 2015

Books and Other Publications

遺伝子治療開発研究ハンドブック

日本遺伝子細胞治療学会, 藤堂, 具紀, 三宅弘一, 島田隆 (Role: Contributor, 低ホスファターゼ症)

エヌ・ティー・エス, Apr, 2023 (ISBN: 9784860438401)
Selected Topics in Neonatal Care

MIYAKE Koichi (Role: Joint author, Neonatal Gene Therapy for Inherited Disorders)

InTech, 2018
Gene Therapy-Principles and Challenges

MIYAKE Koichi (Role: Joint author, Gene delivery into central nervous system (CNS) using AAV vectors)

InTech, 2015
Novel Gene Therapy Approaches

MIYAKE Koichi (Role: Joint author, Development of Muscle-Directed Systemic Cancer Gene Therapy)

InTech, 2013
Viral Gene Therapy

MIYAKE Koichi (Role: Joint author, Development and Application of HIV Vectors Pseudotyped with HIV Envelopes)

InTech, 2011

Presentations

Direct comparison between single-stranded and self-complementary type 9 AAV vector to treat adult MLD model mice by intravenous injection

Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada

he 24th Annual Meeting of Japan Society of Gene Therapy, Jul 26, 2018
Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of adeno-associated virus vector

廣中浩平, 山崎吉之, 平井幸彦, 山本基子, 三宅紀子, 三宅弘一, 島田隆, 岡田尚巳, 喜多村孝幸, 森田明夫

第75回脳神経外科学会学術総会, 2016
Involvement of miR-17-92 cluster in the neuropathic pain and axonal growth.

坂井敦, 三宅紀子, 三宅弘一, 島田隆, 鈴木秀典

第88回日本薬理学会年会, 2015
異染性白質ジストロフィー(MLD)の遺伝子治療基盤研究

三宅紀子, 三宅弘一, 山本基子, 島田隆, 岡田尚巳

2015
アデノ随伴ウイルスベクターの脳室内注入による異染性白色ジストロフィーモデルマウスの遺伝子治療

廣中浩平, 山崎吉之, 平井幸彦, 山本基子, 三宅紀子, 三宅弘一, 森田明夫, 島田隆, 岡田尚巳

第20 回 ?本ライソゾーム病研究会, 2015
Functional analysis of miR-17-92 cluster in chronic pain and neurite outgrowth following nerve injury

坂井敦, 三宅紀子, 丸山基世, 三宅弘一, 島田隆, 岡田尚巳, 鈴木秀典

BMB2015 第38日本分子生物学会年会・第88回日本生化学会合同大会, 2015
Analysis of microRNAs in the primary sensory neurons specifically modulated in the neuropathic pain.

坂井敦, 三宅紀子, 三宅弘一, 島田隆, 鈴木秀典

第36回日本疼痛学会, 2014
Involvement of miR-17-92 cluster in neuropathic pain.

坂井敦, 三宅紀子, 三宅弘一, 島田隆, 鈴木秀典

第37回日本神経科学大会, 2014
Effects of miR-17-92 cluster in the primary sensory neurons on the pain-related behavior and axonal growth.

坂井敦, 三宅紀子, 三宅弘一, 島田隆, 鈴木秀典

第37回日本分子生物学会年会, 2014
DRG神経におけるmiR-7a過剰発現は神経障害性疼痛を特異的に抑制する.

坂井敦, 齋藤文仁, 三宅紀子, 三宅弘一, 島田隆, 鈴木秀典

第35回日本神経科学大会, 2012
AAVベクターによる低ホスファターゼ症の遺伝子治療

松本多絵, 山本晴子, 三宅弘一, 三宅紀子, 小田垣祐子, 折茂英生, 島田隆

第54回人類遺伝学会, 2009
異染性白質ジストロフィーの新生児遺伝子治療

三宅紀子, 三宅弘一, 島田隆

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, 2008
HOXB4発現造血幹細胞移植による異染性白質ジストロフィー (MLD) の治療

三宅紀子, 三宅弘一, 島田隆

第52回日本人類遺伝学会, 2007
HIVベクターを使った網膜新生血管に対する遺伝子治療.

五十嵐勉, 三宅弘一, 加藤美穂, 加藤興, 鈴木紀子, 高橋浩, 大原國俊, 島田隆

第１０６回日本眼科学会総会, 2002
血管新生抑制物質による悪性リンパ腫の遺伝子治療の検討.

三宅弘一, 鈴木紀子, 島田隆

第65回日本血液学会、第45回日本臨床血液学会, 2002
HIVベクターによるATL遺伝子治療の検討

三宅弘一, 鈴木紀子, 島田隆

第63回日本血液学会総会, 2001
角膜上皮幹細胞およびTA細胞への遺伝子導入

五十嵐勉, 三宅弘一, 鈴木紀子, 加藤興, 高橋浩, 大原國俊, 島田隆

第１０５回日本眼科学会総会, 2001
miR-17-92 cluster modulates neuropathic pain and neurite outgrowth

坂井敦, 三宅紀子, 丸山基世, 三宅弘一, 島田隆, 岡田尚巳, 鈴木秀典

第89回日本薬理学会年会

Teaching Experience

Professional Memberships

Research Projects

AI advice for effective PBL assignment creation -Development of assignment writing support tools-

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Development of gene therapy for hypophosphatasia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
機械学習で議事録を分析：PBLチュートリアルチューター支援システムの開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2023

早坂明哲, 藤倉輝道, 根本崇宏, 藤崎弘士, 三宅弘一, 井上千鹿子
脳神経病変を標的とした異染性白質ジストロフィーの新規治療法(遺伝子治療)の開発

科学研究費補助金基盤研究 (C), 文部科学省, 2018 - 2020

三宅紀子
Biomarker development and clinical application by extraction of pathogenesis-related factors from early fibrosis foci of interstitial pneumonia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2017 - 2019

Terasaki Yasuhiro
The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenita

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2016 - 2018

Yamaguchi Hiroki, Terada Kazuki
再生医療実現拠点ネットワークプログラム, 日本医療研究開発機構

2016 - 2018

家田真樹
MicroRNA and exosome in interstitial pneumonia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kunugi Shinobu, MIYAKE KOUICHI, NAGASAKA SHINYA, TERASAKI MIKA, SEIKE MASAHIRO, ISHIKAWA ARIMI, KUWAHARA NAOMI
The gene therapy for hypophosphatasia animal model

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2015 - 2017

Matsumoto Tae
Development a novel gene therapy for Lysosomal disease with neurological disorders

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2015 - 2017

MIYAKE NORIKO
Development of mouse model and therapy of Diamond-Blackfan anemia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2014 - 2017

Miyake Koichi
Comprehensive analysis of neuropathic pain-specific microRNA cluster

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Sakai Atsushi, MIYAKE Koichi
Elucidation of molecular mechanism of survivin in inflammatory lung disease and development of new gene therapy method

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2014 - 2016

Terasaki Mika
Physiological function of the rat SDN-POA analyzed by sst-siRNA recombinant adenovirus vector

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

ORIKASA Chitose, MIYAKA Koichi
Development of regenerative medicine and cell therapy for inherited metabolic diseases using hypophosphatasia mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2013 - 2015

Iijima Osamu, MIYAKE Koichi, SHIMADA Takashi, WATANABE Atsushi
Analysis of lymphoplasmacyte infiltrating fibrotic lung lesion using samples from human lung diseases and RA lung model in D1CC mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2013 - 2015

terasaki yasuhiro, MATSUI Shoko, TERASAKI Mika, MIYAKE Koichi, KANAZAWA Satoshi, KUNUGI Shinobu, OGURA Takashi
Development of novel gene therapy for CNS disorders of lysosomal diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2012 - 2014

MIYAKE NORIKO, MIYAKE Koichi
Analysis of angiogenetic factor in interstitial pneumonia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

KUNUGI Shinobu, TERASAKI Yasuhiro, NAGASAKA Shinya, MIYAKE Kouichi, TAKAHASHI Mikiko
Development of molecular mechanism and therapy of Diamond-Blackfan anemia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

KOICHI Miyake
Perinatal gene therapy for severe genetic diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

SHIMADA Takashi, MIYAKE Koichi, MIGITA Makoto, WATANABE Atsushi

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