2012年8月
チューブリン翻訳後修飾酵素による繊毛の構造・運動制御
生物物理
- ,
- 巻
- 52
- 号
- 4
- 開始ページ
- 178
- 終了ページ
- 181
- 記述言語
- 日本語
- 掲載種別
- 記事・総説・解説・論説等(学術雑誌)
- DOI
- 10.2142/biophys.52.178
- 出版者・発行元
- The Biophysical Society of Japan General Incorporated Association
Post-translational modifications of proteins change dramatically and dynamically protein structures and functions. Tubulin, which forms microtubules, undergoes highly unique post-translational modifications, polyglutamylation and polyglycylation. These modifications, in particular, accumulate in the axoneme of cilia or flagella. Recently, we and others have identified enzymes that perform or reverse those modifications. The discovery of enzymes enables to investigate the physiological roles of the modifications by means of model organisms with knockout or knockdown techniques. We here review recent knowledge, focusing on our own findings, about the roles of polyglutamylation and polyglycylation in ciliary or flagellar structure and motility.<br>
- リンク情報
- ID情報
-
- DOI : 10.2142/biophys.52.178
- ISSN : 0582-4052
- ISSN : 1347-4219
- CiNii Articles ID : 40019396816
- CiNii Books ID : AN00129693