In the new millennium, life science research has entered a new stage to control and manipulate biological/vital phenomenon and then strategically develop the research achievement to practical application, in addition to the achievement of understanding and investigating mechanisms of our life phenomenon. There is also urgent issue for the stakeholders to establish appropriate management systems for storage, sharing, and protection of various biological data collected by human and other animate beings. In the current article, the author introduce recent trends in top-down strategy for research and development as well as the research data management as intellectual property in the United States and European Commission and then discuss how Japanese stakeholders should progress the strategy of life science research and development.