熊谷牧子 (Makiko Koike-Kumagai) - マイポータル

基本情報

J-GLOBAL ID: 201801017171481919
researchmap会員ID: B000314837

論文

Somatostatin-expressing inhibitory neurons with mTORC1 activation in cortical layers 4/5 are involved in the epileptogenesis of mice

Fumiki Yamashita, Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda

Exploration of Neuroscience 3(6) 527-538 2024年10月29日
Sex-based differences in neuropsychiatric symptoms are due to estradiol/ERα-dependent transcriptional regulation via the modulation of steroid levels by sirolimus.

Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda

Pharmacology, biochemistry, and behavior 173875-173875 2024年9月6日
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex

Journal of Experimental Neurology 3(2) 2022年12月13日
Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice.

Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda

Neuropharmacology 218 109203-109203 2022年11月1日査読有り筆頭著者
Clustered Protocadherins Are Required for Building Functional Neural Circuits.

Sonoko Hasegawa, Hiroaki Kobayashi, Makiko Kumagai, Hiroshi Nishimaru, Etsuko Tarusawa, Hiro Kanda, Makoto Sanbo, Yumiko Yoshimura, Masumi Hirabayashi, Takahiro Hirabayashi …

Frontiers in molecular neuroscience 10 114-114 2017年査読有り
Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.

Sonoko Hasegawa, Makiko Kumagai, Mitsue Hagihara, Hiroshi Nishimaru, Keizo Hirano, Ryosuke Kaneko, Atsushi Okayama, Teruyoshi Hirayama, Makoto Sanbo, Masumi Hirabayashi …

Frontiers in molecular neuroscience 9 155-155 2016年査読有り
The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway.

Makiko Koike-Kumagai, Kei-ichiro Yasunaga, Rei Morikawa, Takahiro Kanamori, Kazuo Emoto

The EMBO journal 28(24) 3879-92 2009年12月16日査読有り筆頭著者
The 70-kD heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors.

Shingo Kose, Maiko Furuta, Makiko Koike, Yoshihiro Yoneda, Naoko Imamoto

The Journal of cell biology 171(1) 19-25 2005年10月10日査読有り
beta-Catenin shows an overlapping sequence requirement but distinct molecular interactions for its bidirectional passage through nuclear pores.

Makiko Koike, Shingo Kose, Maiko Furuta, Naoko Taniguchi, Fumihiko Yokoya, Yoshihiro Yoneda, Naoko Imamoto

The Journal of biological chemistry 279(32) 34038-47 2004年8月6日査読有り筆頭著者
Heat-shock induced nuclear retention and recycling inhibition of importin alpha.

Maiko Furuta, Shingo Kose, Makiko Koike, Takeshi Shimi, Yasushi Hiraoka, Yoshihiro Yoneda, Tokuko Haraguchi, Naoko Imamoto

Genes to cells : devoted to molecular & cellular mechanisms 9(5) 429-41 2004年5月査読有り
The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport

S J Lee, N Imamoto, H Sakai, A Nakagawa, S Kose, M Koike, M Yamamoto, T Kumasaka, Y Yoneda, T Tsukihara

J Mol Biol . 302(1) 251-264 2000年9月8日査読有り

MISC

Effect of rapamycin on skin hydration in mouse model of tuberous sclerosis complex

WANG Weining, KATO Kiyoko, MAEDA Shinichiro, KOIKE-KUMAGAI Makiko, KITAYAMA Kazuko, FUJIMOTO Manabu, WATAYA-KANEDA Mari

日本研究皮膚科学会年次学術大会・総会プログラム 44th 225-225 2019年査読有り
ニューロン受容領域のタイル化を制御するリン酸化シグナルネットワーク:ショウジョウバエ感覚神経系をモデルとした解析—The kinase signaling network regulating establishment and maintenance of dendritic tiling: lessons from Drosophila sensory neurons

榎本和生, 小池(熊谷) 牧子

細胞工学 = Cell technology 26(7) 806-810 2007年7月
beta-catenin shows an overlapping sequence requirement but distinct molecular interactions for its bi-directional passage through nuclear pores

Makiko Koike, Shingo Kose, Maiko Furuta, Naoko Taniguchi, Fumihiko Yokoya, Yoshihiro Yoneda, Naoko Imamoto

CELL STRUCTURE AND FUNCTION 29 66-66 2004年5月
Mechanism of stress-induced down regulation of importin alpha/beta transport pathway

OMaiko Furuta, Shinao Kose, Makiko Koike, Takeshi Shimi, Yasushi Hiraoka, Yoshihiro Yoneda, Toqko Haraguchi, Naoko Imamoto

CELL STRUCTURE AND FUNCTION 29 66-66 2004年5月
【細胞内輸送研究の最前線】核-細胞質間輸送の制御機構核-細胞質間輸送の分子機構と輸送経路の多様性

今本尚子, 小池牧子, 古田満衣子

実験医学 21(14) 1842-1849 2003年9月

講演・口頭発表等

Brain estrogen levels are associated with gender differences in neuropsychiatric symptoms in mouse model of tuberous sclerosis complex, and sirolimus may contribute to symptom alleviation by controlling neurosteroid levels.

Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda

The 2024 SID Annual Meeting,
Epilepsy and TAND in the tuberous sclerosis complex are caused by an alteration in microglial polarity to M1 and sirolimus cures them by returning microglial polarity to M2.

Emi Kaneda, Makiko Koike-Kumagai, Mari Wataya-Kaneda

The 2023 International TSC Research Conference,
Sirolimus alters microglial polarity leading to improvement of neuropsychiatric symptoms of tuberous sclerosis complex mice model.

Makiko Koike-Kumagai, Mari Wataya-Kaneda

1 st. International Conference of Neuroscience and Neurology. Hybrid event in Dubai, UAE 2023年6月1日

共同研究・競争的資金等の研究課題

血液脳関門を介さない皮膚から脳への新規薬剤輸送機構の解明

日本学術振興会科学研究費助成事業挑戦的研究(開拓) 2022年6月 - 2025年3月

金田眞理, 望月秀樹, 前田真一郎, 小池・熊谷牧子, 中村歩
結節性硬化症における表現型差異を引き起こす機序の解明

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2021年4月 - 2024年3月

小池・熊谷牧子

熊谷牧子

基本情報

論文

MISC

講演・口頭発表等

共同研究・競争的資金等の研究課題

メニュー

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