論文

国際誌
2015年

Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time.

SpringerPlus
  • Takashi Abe
  • Yoshifumi Mizobuchi
  • Kohei Nakajima
  • Yoichi Otomi
  • Saho Irahara
  • Yuki Obama
  • Mungunkhuyag Majigsuren
  • Delgerdalai Khashbat
  • Teruyoshi Kageji
  • Shinji Nagahiro
  • Masafumi Harada
  • 全て表示

4
開始ページ
88
終了ページ
88
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s40064-015-0861-6

This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL). Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast K (trans) , extravascular extracellular volume V e , and fractional plasma volume V p . We analyzed differences in parameters between tumors using the Mann-Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis. Mean K (trans) values of LGG, HGG, metastasis and PCNSL were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each tumors was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each tumors was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other tumor types, low-grade glioma showed lower K (trans) (P < 0.01, sensitivity = 88%, specificity = 100%) and lower V e (P < 0.01, sensitivity = 96%, specificity = 100%). PCNSL showed higher V e (P < 0.01, sensitivity = 100%, specificity = 88%), but the other perfusion parameters overlapped with those of different histology. Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of brain tumors.

リンク情報
DOI
https://doi.org/10.1186/s40064-015-0861-6
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25793147
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359190
ID情報
  • DOI : 10.1186/s40064-015-0861-6
  • PubMed ID : 25793147
  • PubMed Central 記事ID : PMC4359190

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