論文

査読有り
2019年1月

Physiological responses to central and peripheral injection of polyinosinic-polycytidylic acid in chicks

British Poultry Science
  • T. Tachibana
  • ,
  • Y. Ishimaru
  • ,
  • K. Takeda
  • ,
  • M. S.I. Khan
  • ,
  • R. Makino
  • ,
  • M. A. Cline

60
開始ページ
64
終了ページ
70
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/00071668.2018.1547361

© 2018, © 2018 British Poultry Science Ltd. 1. The purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injection of polyinosinic-polycytidylic acid (poly I:C), a viral mimetic that binds to toll-like receptor-3 (TLR3), affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and crop emptying rate in chicks (Gallus gallus). 2. Both ICV and IP injection of poly I:C significantly decreased food intake. 3. IP but not ICV injection of poly I:C significantly suppressed voluntary activity, whereas ICV injection decreased time spent sitting. Both ICV and IP injection of poly I:C significantly increased plasma CORT and glucose concentration. Neither ICV nor IP injection of poly I:C significantly affected cloacal temperature. 4. In addition, ICV injection of poly I:C significantly reduced crop emptying rate, whereas IP injection had no effect. 5. These results suggested that central TLR3 is related to anorexia, stress response and retardation of crop emptying while peripheral TLR3 is related to anorexia, change in behaviour and stress responses during viral infection in chicks.

リンク情報
DOI
https://doi.org/10.1080/00071668.2018.1547361
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30421962
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058158292&origin=inward

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