論文

査読有り
2010年8月

Feeding and drinking response following central administrations of bombesin-like peptides in chicks

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
  • Tetsuya Tachibana
  • ,
  • Kiyoko Matsuda
  • ,
  • Sakirul Islam Khan
  • ,
  • Hiroshi Ueda
  • ,
  • Mark A. Cline

156
4
開始ページ
394
終了ページ
399
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cbpa.2010.03.008
出版者・発行元
ELSEVIER SCIENCE INC

Gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been isolated as homologues of bombesin. Central administration of bombesin inhibits feeding behavior in chicks (Gallus gallus) while the effects of GRP and NMB have not been reported. The purpose of the present study was to investigate whether intracerebroventricular (ICV) injection of GRP, NMB and neuromedin C (NMC, the C-terminus decapeptide of GRP) affected feeding and drinking behavior in chicks. Injection of GRP, NMC and NMB (0.2-5 nmol) decreased feeding behavior in chicks while drinking behavior was not affected. ICV injection of 5 nmol GRP and NMC decreased voluntary locomotion while NMB did not. It is therefore possible that GRP- and NMC-associated hypoactivity is related to the peptides' anorexigenic effects. GRP, NMC and NMB did not affect plasma corticosterone concentration, suggesting that hypothalamus-pituitary-adrenal axis might not be related to the anorexigenic action of these peptides. All these findings support the hypothesis that GRP. NMC and NMB function as anorexigenic factors in the brain of chicks. (C) 2010 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1016/j.cbpa.2010.03.008
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20233609
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279582000004&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952967724&origin=inward

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