論文

査読有り
2010年6月

Combination Therapy with Antiviral Drugs and Hepatitis B Vaccine in Incidentally-Detected and Asymptomatic Chronic Hepatitis Virus B Carriers at Bangladesh

VIRAL IMMUNOLOGY
  • Mamun Al-Mahtab
  • ,
  • Salimur Rahman
  • ,
  • Sheikh Mohammad Fazle Akbar
  • ,
  • Sakirul Islam Khan
  • ,
  • Helal Uddin
  • ,
  • Fazal Karim
  • ,
  • Faroque Ahmed

23
3
開始ページ
335
終了ページ
338
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1089/vim.2009.0104
出版者・発行元
MARY ANN LIEBERT INC

Asymptomatic chronic hepatitis B virus (HBV) carriers are at risk of developing complications of liver disease, but these patients are not recommended for treatment with antiviral drugs. In fact, antiviral drugs are ineffective in these patients in the immune tolerance phase, when they have inadequate levels of host immunity. We postulated that combination therapy of an immune modulator and antiviral drugs may have potential to help these patients. Twenty-five patients with incidentally-detected asymptomatic chronic HBV were immunized with hepatitis B vaccine (10 mg of hepatitis B surface antigen) intramuscularly five times (at 0, 1, 2, 6, and 12 mo) to induce HBV-specific immunity. The patients were also treated with lamivudine (100 mg) daily for 12 mo. The combination therapy was safe for all patients with asymptomatic chronic HBV, and no increases in alanine aminotransferase or liver damage were detected in any patient. Although all of the patients were expressing HBV DNA in their serum before treatment, HBV DNA became undetectable in 16 of 25 patients, and was reduced in 9 of 25 patients at the end of the combination therapy. Combination therapy with the antiviral agent lamivudine and an immune modulator (hepatitis B vaccine) represents a potential therapeutic option for the control of HBV without liver damage in asymptomatic chronic HBV carriers.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1089/vim.2009.0104
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20565297
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000278974400011&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954172716&origin=inward

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