論文

査読有り
2010年2月

Central administration of substance P inhibits feeding behavior in chicks

HORMONES AND BEHAVIOR
  • Tetsuya Tachibana
  • ,
  • Md. Sakirul Islam Khan
  • ,
  • Kiyoko Matsuda
  • ,
  • Hiroshi Ueda
  • ,
  • Mark A. Cline

57
2
開始ページ
203
終了ページ
208
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.yhbeh.2009.11.001
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

The purpose of the present study was to determine whether central administration of substance P (SP), a tachykinin neuropeptide, influenced feeding behavior in layer chicks (Gallus gallus). Intracerebroventricular (ICV) injections of 5 nmol SP decreased food intake in 5- and 6-day-old chicks under both ad libitum and 3-h fasting conditions. There are 3 major subtypes of tachykinin receptors, namely, neurokinin 1, 2 and 3 receptors. Injection of neurokinin A and neurokinin B, which are respectively endogenous agonists for neurokinin 2 and 3 receptors, did not suppress feeding behavior in chicks, suggesting that the anorexigenic effect of SP might be mediated by the neurokinin 1 receptor rather than neurokinin 2 and 3 receptors. Chicks that received 5 nmol SP did not change their locomotion, standing, sitting or drinking time, suggesting that its anorexigenic action might not be due to SP-induced hyperactivity or sedation. ICV injection of SP increased water intake, also indicating that SP likely did not affect feeding behavior through malaise. In addition, the anorexigenic effect of SP might not be related to corticotrophin-releasing hormone (CRH) because plasma corticosterone concentration was not affected by ICV injection of SP and co-administration of the CRH receptor antagonist astressin did not affect the anorexigenic effect of SP. The present study suggests that central SP acts as an anorexigenic neuropeptide in chicks. (c) 2009 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1016/j.yhbeh.2009.11.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19909753
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000274434100015&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=74749093376&origin=inward

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