2010
Combination therapy of lamivudine and interferon-alpha in pediatric patients with chronic hepatitis B in Bangladesh: A safe and effective therapeutic approach for pediatric CHB patients in developing countries
International Journal of Immunopathology and Pharmacology
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- Volume
- 23
- Number
- 2
- First page
- 659
- Last page
- 664
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1177/039463201002300231
- Publisher
- Biomedical Research Press s.a.s.
Hepatitis B virus (HBV) is mainly transmitted during birth or perinatal period, however, treatment is not usually recommended for pediatric patients with chronic hepatitis B (CHB). Twelve pediatric patients with CHB in Bangladesh were treated with both lamivudine and interferon. Lamivudine was given at a dose of 3 mg/kg, daily for 12 months. Two months after commencement of lamivudine therapy, all patents were given interferon-α (3 million IU/square meter of body surface area) three times weekly, subcutaneously for 10 months. Combination therapy was safe for all pediatric CHB patients. The levels' of serum HBV DNA became undetectable (<
500 copies/ml) in 8 patients and reduced in 4 patients after the end of therapy. Anti-HBe was detected in 10 of 12 patients at this time point. The levels of serum alanine aminotransferase (ALT) were significantly reduced in these patients (p<
0.05) due to therapy. Neither flare of HBV DNA nor elevation of serum ALT were detected during follow-up. In conclusion, combination therapy with lamivudine and interferon-α represents a new and novel therapeutic option for treatment of pediatric CHB patients. Copyright © by BIOLIFE, s.a.s.
500 copies/ml) in 8 patients and reduced in 4 patients after the end of therapy. Anti-HBe was detected in 10 of 12 patients at this time point. The levels of serum alanine aminotransferase (ALT) were significantly reduced in these patients (p<
0.05) due to therapy. Neither flare of HBV DNA nor elevation of serum ALT were detected during follow-up. In conclusion, combination therapy with lamivudine and interferon-α represents a new and novel therapeutic option for treatment of pediatric CHB patients. Copyright © by BIOLIFE, s.a.s.
- Link information
- ID information
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- DOI : 10.1177/039463201002300231
- ISSN : 0394-6320
- Pubmed ID : 20646364
- SCOPUS ID : 77955376631