論文

査読有り
2009年6月

Central administration of metastin increases food intake through opioid neurons in chicks

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
  • Md. Sakirul Islam Khan
  • ,
  • Takeshi Ohkubo
  • ,
  • Naoto Masuda
  • ,
  • Tetsuya Tachibana
  • ,
  • Hiroshi Ueda

153
2
開始ページ
209
終了ページ
212
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cbpa.2009.02.013
出版者・発行元
ELSEVIER SCIENCE INC

Metastin, an RFamide peptide, has been isolated from human placenta and possesses several physiological actions in mammals. However, little is known about this bioactive peptide in avian species. This study was conducted to assess the effect of metastin on feeding behavior of chicks (Gallus gallus). The food intake of chicks is significantly increased by the intracerebroventricular injection of metastin. Beta-funaltrexamine, a mu-opioid receptor antagonist, significantly attenuates metastin-induced food intake in chicks. In contrast, delta- and kappa-opioid receptor antagonists did not show any influence on metastin-induced food intake in chicks. In addition, administration of W-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, did not influence metastin-induced food intake. Taken together, this study shows the orexigenic effect of metastin in chicks and suggests that this effect is mediated by mu-opioid receptor. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1016/j.cbpa.2009.02.013
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19232396
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000266229400018&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=64949115987&origin=inward

エクスポート
BibTeX RIS