論文

査読有り
2006年

Intracerebroventricular Administration of Growth Hormone Releasing Peptide-6 (GHRP-6) Inhibits Food Intake, but not Food Retention of Crop and Stomaeh in Neonatal Chicks

Journal of Poultry Science
  • Md. Sakirul Islam Khan
  • ,
  • Koh-Ichi Dodo
  • ,
  • Kazuki Yahata
  • ,
  • Sayuri Nishimoto
  • ,
  • Hiroshi Ueda
  • ,
  • Tetsuro Taneike
  • ,
  • Takio Kitazawa
  • ,
  • Yoshinao Hosaka
  • ,
  • Takashi Bungo

43
1
開始ページ
35
終了ページ
40
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2141/jpsa.43.35

Growth hormone secretagogues (GHS), including ghrelin, are known to stimulate feeding behavior in mammals. In contrast, intracerebroventricular (ICV) injection of rat or chicken ghrelin, strongly inhibits food intake in chicks. The difference prompted us to compare the effect of growth hormone releasing peptide-6 (GHRP-6), one of synthetic GHSs on feeding behavior of chicks with that of ghrelin. Gastric motility stimulating action of GHRP-6 was also examined in vivo measuring retention of food in digestive tracts. ICV injection of GHRP-6 (0.38 nmol-1.5 nmol) dose-dependentiy inhibited food intake of neonatal chicks under both ad libitum and fasting conditions. The anorexic effect of GHRP-6 was attenuated by D-Lys3-GHRP-6 (GHS receptor antagonist) in a dose dependent manner. Central injection of GHS agonist and/or antagonist did not affect food retention in crop, proventriculus and gizzard. These results suggest that central injection of synthetic GHS, GHRP-6 inhibits feeding behavior as dose ghrelin without affecting gastrointestinal motility in layer chicks. © 2006, Japan Poultry Science Association. All rights reserved.

リンク情報
DOI
https://doi.org/10.2141/jpsa.43.35

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