論文

査読有り 国際誌
2020年7月

Behavioral and physiological responses to intraperitoneal injection of zymosan in chicks.

Domestic animal endocrinology
  • T Tachibana
  • ,
  • A Nakatani
  • ,
  • M S Islam Khan
  • ,
  • R Makino
  • ,
  • M A Cline

72
開始ページ
106471
終了ページ
106471
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.domaniend.2020.106471

Zymosan is a cell wall component of the yeast Saccharomyces cerevisiae and produces severe inflammatory responses in mammals. When zymosan is peripherally injected in mammals, it induces several behavioral and physiological changes including anorexia and hyperthermia. However, to our knowledge, behavioral and physiological responses to zymosan have not yet been clarified in birds. Therefore, the purpose of the present study was to determine if intraperitoneal injection of zymosan affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and splenic gene expression of cytokines in chicks (Gallus gallus). Intraperitoneal injection of zymosan (2.5 mg) significantly decreased food intake, voluntary activity, and plasma glucose concentration, and increased plasma CORT concentration. The injection of 0.5 mg zymosan significantly increased cloacal temperature, while 2.5 mg zymosan had a tendency to increase it. Finally, 2.5 mg zymosan significantly increased the splenic gene expression of interleukin-1β (IL-1β), IL-6, IL-8, interferon-γ, and tumor necrosis factor-like cytokine 1A. The present results suggest that zymosan would be one of components which induces nonspecific symptoms including anorexia, hypoactivity, hyperthermia, and stress responses, under fungus infection in chicks.

リンク情報
DOI
https://doi.org/10.1016/j.domaniend.2020.106471
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32279040

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