Aug, 2020
Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Volume
- 29
- Number
- 8
- First page
- 104818
- Last page
- 104818
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/j.jstrokecerebrovasdis.2020.104818
BACKGROUND: During an acute stroke, reactive oxygen species are overproduced and the endogenous antioxidative defense systems are disrupted. Therefore, antioxidative therapy can be a promising scheme to reduce the severity of stroke. Neumentix is a novel antioxidative supplement produced from a patented mint line and contains a high content of rosmarinic acid (RA). Although Neumentix has proven diverse efficacy and safety in clinical trials, its effect on strokes is unclear. METHODS: Mice that were treated with Neumentix or vehicle for 14 days underwent transient middle cerebral artery occlusion (tMCAO) for 60 min. Mice were sacrificed 5 days after tMCAO. RESULTS: Neumentix preserved body weight after tMCAO, showed a high antioxidative effect in serum, and reduced infarction volume compared to the vehicle. The expression of 4-hydroxy-2-nonenal, Nε-(carboxymethyl) lysine, and 8-hydroxy-2'-deoxyguanosine was reduced in Neumentix-treated mice. CONCLUSION: The antioxidative effect of Neumentix was confirmed. This is the first report to demonstrate the antioxidative effect of Neumentix on strokes.
- Link information
- ID information
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- DOI : 10.1016/j.jstrokecerebrovasdis.2020.104818
- Pubmed ID : 32439352