Apr, 2020
Discrepancy of subjective and objective sleep problems in Alzheimer's disease and mild cognitive impairment detected by a home-based sleep analysis
JOURNAL OF CLINICAL NEUROSCIENCE
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- Volume
- 74
- Number
- First page
- 76
- Last page
- 80
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/j.jocn.2020.01.085
- Publisher
- ELSEVIER SCI LTD
There is a strong relationship between Alzheimer's disease (AD) and sleep problems, and a sleep condition is informative for evaluating the AD status. In the present study, we evaluated subjective sleep problems in AD and mild cognitive impairment (MCI) with self-check questionnaires and objective sleep problems with a convenient home-based portable device, WatchPAT. A total of 63 subjects with normal cognition (NC) (n = 22), MCI (n = 20), and AD (n = 21) were cross-sectionally investigated. AD patients showed a better self-check Pittsburgh sleep quality index (PSQI) score (*p < 0.05) than NC and MCI patients. On the other hand, WatchPAT analysis showed a significantly reduced rapid eye movement (REM) sleep (*p < 0.05) and increased light sleep in AD patients (*p < 0.05) compared with NC subjects, and mildly reduced REM and increased light sleep in MCI subjects. The present study revealed a gap between the subjective self-check sleep questions and the objective WatchPAT analysis in AD patients. Thus, a home-based sleep study with WatchPAT is a useful tool to detect an objective sleep problem in AD and the risk of MCI conversion into AD. (C) 2020 Elsevier Ltd. All rights reserved.
- Link information
- ID information
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- DOI : 10.1016/j.jocn.2020.01.085
- ISSN : 0967-5868
- eISSN : 1532-2653
- Web of Science ID : WOS:000527311400014