Papers

May, 2019

Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis

JOURNAL OF NEUROSCIENCE RESEARCH
  • Yasuyuki Ohta
  • Emi Nomura
  • Jingwei Shang
  • Tian Feng
  • Yong Huang
  • Xia Liu
  • Xiaowen Shi
  • Yumiko Nakano
  • Nozomi Hishikawa
  • Kota Sato
  • Mami Takemoto
  • Toru Yamashita
  • Koji Abe
  • Display all

Volume
97
Number
5
First page
607
Last page
619
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/jnr.24368
Publisher
WILEY

Oxidative stress is associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). A free radical scavenger edaravone has been proven as a therapeutic drug for ALS patients, but the neuroprotective mechanism for the oxidative stress of ALS has not been fully investigated. In this study, we investigated oxidative stress in ALS model mice bearing both oxidative stress sensor nuclear erythroid 2-related factor 2 (Nrf2) and G93A-human Cu/Zn superoxide dismutase (Nrf2/G93A) treated by edaravone. In vivo Nrf2 imaging analysis showed the accelerated oxidative stress both in spinal motor neurons and lower limb muscles of Nrf2/G93A mice according to disease progression in addition to the enhancement of serum oxidative stress marker dROMS. These were significantly alleviated by edaravone treatment accompanied by clinical improvements (rotarod test). The present study suggests that in vivo optical imaging of Nrf2 is useful for detecting oxidative stress in ALS, and edaravone alleviates the degeneration of both motor neurons and muscles related to oxidative stress in ALS patients.

Link information
DOI
https://doi.org/10.1002/jnr.24368
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000461891200008&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/jnr.24368
  • ISSN : 0360-4012
  • eISSN : 1097-4547
  • Web of Science ID : WOS:000461891200008

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