May, 2021
Positive baseline behavioral and psychological symptoms of dementia predict a subsequent cognitive impairment in cognitively normal population
NEUROLOGY AND CLINICAL NEUROSCIENCE
- Volume
- 9
- Number
- 3
- First page
- 218
- Last page
- 222
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1111/ncn3.12492
- Publisher
- WILEY
Background: Because behavioral and psychological symptoms of dementia (BPSD) are sometimes prodromal symptoms of dementia, it is important to investigate the relationship between BPSD and subsequent cognitive decline.Methods: We examined the cognitive and affective functions of 76 cognitively normal subjects at initial assessment (baseline) and 1-year follow-up. Cognitive function was assessed using clinical dementia rating (CDR) and Mini-Mental State Examination (MMSE), and affective function was assessed using Abe's BPSD score (ABS) and mild behavioral impairment (MBI).Results: Although there was no change in MMSE, ABS, or MBI after 1 year, the mean CDR score of 0 at baseline increased to 0.1 +/- 0.2 at 1-year follow-up (**P < 0.01 vs baseline). No significant change in MMSE was found in both baseline ABS and MBI positive- or negative-groups. In contrast, baseline MBI-dependent CDR change showed a 13.2% of worsening in MBI-negative subjects and a 62.5% of MBI-positive subjects (dagger dagger P < 0.01), but ABS not.Conclusion: The present data indicate that positive baseline BPSD with MBI was closely related to a subsequent CDR exacerbation. Examining BPSD may be useful for screening cognitively normal population for subsequent dementia development in local communities.
- Link information
- ID information
-
- DOI : 10.1111/ncn3.12492
- ISSN : 2049-4173
- Web of Science ID : WOS:000632979200001