COBAN Cevayir (Cevayir COBAN) - マイポータル

基本情報

所属: The Institute of Medical Science (IMSUT), The University of Tokyo Department of Microbiology and Immunology, Division of Malaria Immunology Professor
: Osaka University, IFReC Guest Professor

学位: MD(Hacettepe University School of Medicine)
Clinical Microbiology(Ankara Numune Education and Research Hospital (Current name: Ankara City Hospital of University of Health Sciences)

ORCID iD: https://orcid.org/0000-0002-4467-7799
researchmap会員ID: B000301545

外部リンク: https://www.ims.u-tokyo.ac.jp/malimmun/

Immunology, Parasitology, Infectious Diseases, Malaria, Plasmodium, Cerebral Malaria, Osteoporosis, Vitamin D, Bone loss, osteoimmunology

研究キーワード

研究分野

ライフサイエンス / 免疫学 /

経歴

2019年 - 現在

The Institute of Medical Science (IMSUT), The University of Tokyo, Division of Malaria Immunology, Professor
2015年 - 2020年

Osaka University, Immunology Frontier Research Center, Laboratory of Malaria Immunology, Professor
2010年 - 2015年

Osaka University, Immunology Frontier Research Center, Laboratory of Malaria Immunology, Associate Professor
2003年 - 2009年

Osaka University, Department of Host Defense, Assistant Professor/Postdoc
2000年 - 2003年

Johns Hopkins University, School of Public Health, Malaria Research Institute, Postdoctoral Fellow

受賞

2017年

Women Immunologist Award, Japanese Society of Immunology

Cevayir COBAN

主要な論文

100

MyD88 in osteoclast and osteoblast lineages differentially controls bone remodeling in homeostasis and malaria.

Jalal Alshaweesh, Rashmi Dash, Michelle S J Lee, Pinar Kahyaoglu, Ece Erci, Mengling Xu, Julia Matsuo-Dapaah, Camila Del Rosario Zorrilla, Kubra Aykac, Suheyla Ekemen …

International immunology 36(9) 451-464 2024年8月13日査読有り責任著者
Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells.

Michelle Sue Jann Lee, Julia Matsuo-Dapaah, Camila Del Rosario Zorrilla, Yoshiki Omatsu, Takashi Nagasawa, Shun Uemura, Atsushi Iwama, Ken J Ishii, Cevayir Coban

International immunology 36(7) 339-352 2024年6月8日査読有り
Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites.

Yuki S Tateishi, Tamasa Araki, Satoru Kawai, Shuhei Koide, Yuko Umeki, Takashi Imai, Yumiko Saito-Nakano, Masaki Kikuchi, Atsushi Iwama, Hajime Hisaeda …

Parasitology international 100 102856-102856 2024年6月査読有り
The Programmed Cell Death Ligand 1 and Lipocalin 2 Expressions in Primary Breast Cancer and Their Associations with Molecular Subtypes and Prognostic Factors.

Suheyla Ekemen, Ebru Bilir, Hagar Elsayed Akram Soultan, Sadia Zafar, Figen Demir, Babek Tabandeh, Sadik Toprak, Ozlem Yapicier, Cevayir Coban

Breast cancer (Dove Medical Press) 16 1-13 2024年査読有り
Diagnostic challenges in cutaneous leishmaniasis due to atypical Leishmania infantum: pathologists' insights from re-emergence zones.

Suheyla Ekemen, Muhammed Nalcaci, Seray Toz, Chizu Sanjoba, Cuyan Demirkesen, Emel D Cetin, Tulay Tecimer, Pelin Yildiz, Mayda Gursel, Umit Ince …

Frontiers in medicine 11 1453211-1453211 2024年査読有り
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation.

Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto …

Frontiers in immunology 15 1353336-1353336 2024年査読有り
Endometrial Staining of CD56 (Uterine Natural Killer), BCL-6, and CD138 (Plasma Cells) Improve Diagnosis and Clinical Pregnancy Outcomes in Unexplained Infertility and Recurrent IVF Failures: Standardization of Diagnosis with Digital Pathology.

Suheyla Ekemen, Cem Comunoglu, Cavit Kerem Kayhan, Ebru Bilir, Ilkay Cavusoglu, Nilay Etiler, Selcuk Bilgi, Umit Ince, Cevayir Coban, Halit Firat Erden

Diagnostics (Basel, Switzerland) 13(9) 2023年4月26日査読有り
Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation.

Burcu Temizoz, Kou Hioki, Shingo Kobari, Nao Jounai, Takato Kusakabe, Michelle S J Lee, Cevayir Coban, Etsushi Kuroda, Ken J Ishii

International immunology 34(7) 353-364 2022年4月14日査読有り
TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.

Fabian A Fischer, Linda F M Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C Kagan …

Proceedings of the National Academy of Sciences of the United States of America 118(38) 2021年9月21日査読有り
Using a new three-dimensional CUBIC tissue-clearing method to examine the brain during experimental cerebral malaria.

Julia Matsuo-Dapaah, Michelle Sue Jann Lee, Ken J Ishii, Kazuki Tainaka, Cevayir Coban

International immunology 2021年8月29日査読有り
The host targeting effect of chloroquine in malaria.

Cevayir Coban

Current opinion in immunology 66 98-107 2020年8月18日査読有り
Heparin induces neutrophil elastase-dependent vital and lytic NET formation.

Patrick M Lelliott, Masatoshi Momota, Takayuki Shibahara, Michelle S J Lee, Nicholas I Smith, Ken J Ishii, Cevayir Coban

International immunology 32(5) 359-368 2020年5月8日査読有り
B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant.

Lee MSJ, Natsume-Kitatani Y, Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, Kobiyama K, Kuroda E …

European journal of immunology 49(9) 1433-1440 2019年9月1日査読有り
Rapid Quantification of NETs In Vitro and in Whole Blood Samples by Imaging Flow Cytometry

Patrick M. Lelliott, Masatoshi Momota, Michelle S.J. Lee, Etsushi Kuroda, Norifumi Iijima, Ken J. Ishii, Cevayir Coban

Cytometry Part A 95(5) 565-578 2019年5月査読有り
Mucosal vaccine for malaria

Michelle Sue Jann Lee, Cevayir Coban

Mucosal Vaccines: Innovation for Preventing Infectious Diseases 831-840 2019年1月1日査読有り
Does it take three to tango? An unsuspected multimorbidity of CD8⁺ T cell lymphoproliferative disorder, malaria, and EBV infection.

Ekemen S, Uzay A, Bassullu N, Dikicioglu-Cetin E, Matsuda K, Ince U, Coban C

Malaria journal 17(1) 349 2018年10月査読有り
Tissue-specific immunopathology during malaria infection

Cevayir Coban, Michelle Sue Jann Lee, Ken J. Ishii

Nature Reviews Immunology 18(4) 266-278 2018年4月査読有り
Unforeseen pathologies caused by malaria

Michelle Sue Jann Lee, Cevayir Coban

International Immunology 30(3) 121-129 2018年3月1日査読有り
Plasmodium products persist in the bone marrow and promote chronic bone loss

Michelle S.J. Lee, Kenta Maruyama, Yukiko Fujita, Aki Konishi, Patrick M. Lelliott, Sawako Itagaki, Toshihiro Horii, Jing wen Lin, Shahid M. Khan, Etsushi Kuroda …

Science Immunology 2(12) 2017年査読有り
IFN-γ protects hepatocytes against Plasmodium vivax infection via LAP-like degradation of sporozoites.

Lelliott PM, Coban C

Proceedings of the National Academy of Sciences of the United States of America 113(25) 6813-6815 2016年6月査読有り
Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation

Michelle Sue Jann Lee, Yoshikatsu Igari, Toshihiro Tsukui, Ken J. Ishii, Cevayir Coban

VACCINE 34(18) 2055-2061 2016年4月査読有り
Label-free Raman imaging of the macrophage response to the malaria pigment hemozoin

Alison J. Hobro, Nicolas Pavillon, Katsumasa Fujita, Muge Ozkan, Cevayir Coban, Nicholas I. Smith

ANALYST 140(7) 2350-2359 2015年査読有り
Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine

Ryuta Uraki, Subash C. Das, Masato Hatta, Maki Kiso, Kiyoko Iwatsuki-Horimoto, Makoto Ozawa, Cevayir Coban, Ken J. Ishii, Yoshihiro Kawaoka

VACCINE 32(41) 5295-5300 2014年9月査読有り
Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

Hong Zhao, Taiki Aoshi, Satoru Kawai, Yuki Mori, Aki Konishi, Muge Ozkan, Yukiko Fujita, Yasunari Haseda, Mikiko Shimizu, Masako Kohyama …

Cell host & microbe 15(5) 551-63 2014年5月14日査読有り
Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets

Motoyasu Onishi, Mitsutaka Kitano, Keiichi Taniguchi, Tomoyuki Homma, Masanori Kobayashi, Akihiko Sato, Cevayir Coban, Ken J. Ishii

VACCINE 32(25) 3004-3009 2014年5月査読有り
DNA vaccines A simple DNA sensing matter?

Cevayir Coban, Kouji Kobiyama, Nao Jounai, Miyuki Tozuka, Ken J. Ishii

HUMAN VACCINES & IMMUNOTHERAPEUTICS 9(10) 2216-2221 2013年10月査読有り
Raman spectroscopic analysis of malaria disease progression via blood and plasma samples

Alison J. Hobro, Aki Konishi, Cevayir Coban, Nicholas I. Smith

ANALYST 138(14) 3927-3933 2013年査読有り
Detection and size measurement of individual hemozoin nanocrystals in aquatic environment using a whispering gallery mode resonator

Woosung Kim, Sahin Kaya Ozdemir, Jiangang Zhu, Monifi Faraz, Cevayir Coban, Lan Yang

OPTICS EXPRESS 20(28) 29426-29446 2012年12月査読有り
Lipocalin 2 Bolsters Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection by Reinforcing Host Iron Metabolism

Hong Zhao, Aki Konishi, Yukiko Fujita, Masanori Yagi, Keiichi Ohata, Taiki Aoshi, Sawako Itagaki, Shintaro Sato, Hirotaka Narita, Noha H. Abdelgelil …

CELL HOST & MICROBE 12(5) 705-716 2012年11月査読有り
Novel Strategies to Improve DNA Vaccine Immunogenicity

Cevayir Coban, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Toshihiro Horii, Shizuo Akira, Ken J. Ishii

CURRENT GENE THERAPY 11(6) 479-484 2011年12月査読有り
Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax

Fadile Yildiz Zeyrek, Nirianne Palacpac, Fehmi Yuksel, Masanori Yagi, Kaori Honjo, Yukiko Fujita, Nobuko Arisue, Satoru Takeo, Kazuyuki Tanabe, Toshihiro Horii …

PLOS ONE 6(11) e28126 2011年11月査読有り
TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

Cevayir Coban, Toshihiro Horii, Shizuo Akira, Ken J. Ishii

EXPERT REVIEW OF VACCINES 9(7) 775-784 2010年7月査読有り
Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9

Cevayir Coban, Yoshikatsu Igari, Masanori Yagi, Thornik Reimer, Shohei Koyama, Taiki Aoshi, Keiichi Ohata, Toshihiro Tsukui, Fumihiko Takeshita, Kazuo Sakurai …

CELL HOST & MICROBE 7(1) 50-61 2010年1月査読有り
The malarial metabolite hemozoin and its potential use as a vaccine adjuvant

Cevayir Coban, Masanori Yagi, Keiichi Ohata, Yoshikatsu Igari, Toshihiro Tsukui, Toshihiro Horii, Ken J Ishii, Shizuo Akira

Allergology International 59(2) 115-124 2010年査読有り
Immune Interventions of Human Diseases through Toll-Like Receptors

Cevayir Coban, Ken J. Ishii, Shizuo Akira

PHARMACEUTICAL BIOTECHNOLOGY 655 63-80 2009年査読有り
Host innate immune receptors and beyond: Making sense of microbial infections

Ken J. Ishii, Shohei Koyama, Atsushi Nakagawa, Cevayir Coban, Shizuo Akira

CELL HOST & MICROBE 3(6) 352-363 2008年6月査読有り
Short report: Analysis of naturally acquired antibody responses to the 19-kd C-terminal region of merozoite surface protein-1 of plasmodium vivax from individuals in Sanliurfa, Turkey

Fadile Yildiz Zeyrek, Aylin Babaoglu, Seda Demirel, Derya Dirim Erdogan, Mucide Ak, Metin Korkmaz, Cevayir Coban

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 78(5) 729-732 2008年5月査読有り
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Ken J. Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban …

NATURE 451(7179) 725-U6 2008年2月査読有り
Molecular and cellular mechanisms of DNA vaccines

Cevayir Coban, Shohei Koyama, Fumihiko Takeshita, Shizuo Akira, Ken J. Ishii

Human Vaccines 4(6) 453-456 2008年査読有り
Manipulation of host innate immune responses by the malaria parasite

Cevayir Coban, Ken J. Ishii, Toshihiro Horii, Shizuo Akira

TRENDS IN MICROBIOLOGY 15(6) 271-278 2007年6月査読有り
Pathological role of Toll-like receptor signaling in cerebral malaria

Cevayir Coban, Ken J. Ishii, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii …

INTERNATIONAL IMMUNOLOGY 19(1) 67-79 2007年1月査読有り
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA

KJ Ishii, C Coban, H Kato, K Takahashi, Y Torii, F Takeshita, H Ludwig, G Sutter, K Suzuki, H Hemmi …

NATURE IMMUNOLOGY 7(1) 40-48 2006年1月査読有り
Manifold mechanisms of toll-like receptor-ligand recognition

KJ Ishii, C Coban, S Akira

JOURNAL OF CLINICAL IMMUNOLOGY 25(6) 511-521 2005年11月査読有り
Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors

C Coban, KJ Ishii, M Gursel, DM Klinman, N Kumar

JOURNAL OF LEUKOCYTE BIOLOGY 78(3) 647-655 2005年9月査読有り
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

C Coban, KJ Ishii, T Kawai, H Hemmi, S Sato, S Uematsu, M Yamamoto, O Takeuchi, S Itagaki, N Kumar …

JOURNAL OF EXPERIMENTAL MEDICINE 201(1) 19-25 2005年1月査読有り
Induction of Plasmodium falciparum transmission-blocking antibodies in nonhuman primates by a combination of DNA and protein immunizations

C Coban, MT Philipp, JE Purcell, DB Keister, M Okulate, DS Martin, N Kumar

INFECTION AND IMMUNITY 72(1) 253-259 2004年1月査読有り
Effect of CpG oligodeoxynucleotides on the immunogenicity of Pfs25, a Plasmodium falciparum transmission-blocking vaccine antigen

C Coban, KJ Ishii, AW Stowers, DB Keister, DM Klinman, N Kumar

INFECTION AND IMMUNITY 72(1) 584-588 2004年1月査読有り
Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the Isotype of antibodies induced by a DNA vaccine

C Coban, KJ Ishii, DJ Sullivan, N Kumar

INFECTION AND IMMUNITY 70(7) 3939-3943 2002年7月査読有り
Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection

DM Klinman, J Conover, C Coban

INFECTION AND IMMUNITY 67(11) 5658-5663 1999年11月査読有り

もっとみる

MISC

DNA Vaccine: Does it Target the Double Stranded-DNA Sensing Pathway?

Cevayir Coban, Miyuki Tozuka, Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita, Choon Kit Tang, Choon Kit Tang, Choon Kit Tang, Ken J. Ishii, Ken J. Ishii

Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology 257-270 2013年11月1日
DNAワクチンのあらたな免疫学的作用機序 (第1土曜特集最新免疫研究Update--免疫システム研究から免疫疾患の病態制御・治療へ) -- (感染症)

青枝大貴, 小山正平, Coban Cevayir

医学のあゆみ 227(5) 387-392 2008年11月1日
脳マラリアの発症とTLR--マラリア原虫と宿主自然免疫の攻防 (特集免疫応答とToll-like receptor(TLR))

石井健, Cevayir Coban, 審良静男

臨床免疫・アレルギー科 49(3) 265-273 2008年3月

COBAN Cevayir

基本情報

研究キーワード

研究分野

経歴

受賞

主要な論文

MISC

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