論文

査読有り
1999年10月

Appearance and disappearance of Syk family protein-tyrosine kinase genes during metazoan evolution

GENE
  • RE Steele
  • ,
  • NA Stover
  • ,
  • M Sakaguchi

239
1
開始ページ
91
終了ページ
97
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0378-1119(99)00373-X
出版者・発行元
ELSEVIER SCIENCE BV

Syk family protein-tyrosine kinases are essential components of immunoreceptor signaling in mammalian lymphocytes. The absence of Syk genes from the Caenorhabiditis elegans genome suggests that this kinase family is of recent evolutionary origin. Surprisingly, we have found that Hydra vulgaris, a member of the early diverging animal phylum Cnidaria, contains a gene encoding a Syk kinase. Phylogenetic analysis indicates that a single Syk family gene was present in animals prior to the gene duplication that gave rise to Syk and ZAP-70, the two mammalian Syk family genes. C. elegans also lacks a Shark protein-tyrosine kinase gene, which we show is a member of a sister group to the Syk family. We conclude that both Syk and Shark genes were lost from the genome of an ancestor of C. elegans. This natural gene knockout result indicates that neither Syk nor Shark kinases are essential for processes held in common between the nematode and other metazoans. The Hydra Syk gene is expressed in epithelial cells, a site consistent with a role for Hydra Syk in recognition of foreign cells. (C) 1999 Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 29

リンク情報
DOI
https://doi.org/10.1016/S0378-1119(99)00373-X
CiNii Articles
http://ci.nii.ac.jp/naid/80010741922
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10571038
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083291600010&DestApp=WOS_CPL

エクスポート
BibTeX RIS