2020年2月27日
The endocyclic oxygen atom of D-mannopyranose is involved in its binding to pradimicins
TETRAHEDRON LETTERS
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- 巻
- 61
- 号
- 9
- DOI
- 10.1016/j.tetlet.2019.151530
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Methyl 5-thio-alpha-D-mannopyranoside (1) and six inositols were evaluated for their ability to bind to pradimicins (PRMs) via molecular modeling and three binding assays. In all the experiments, the binding affinity of 1 was slightly lower than that of methyl alpha-D-mannopyranoside (Man-OMe) and inositols hardly bound to PRMs. These results indicate that the endocyclic oxygen atom of Man-OMe is involved in its binding to PRMs. (C) 2019 Elsevier Ltd. All rights reserved.
- ID情報
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- DOI : 10.1016/j.tetlet.2019.151530
- ISSN : 0040-4039