Background: Food-dependent exercise-induced anaphylaxis (FDEIA) is characterized by anaphylactic symptoms after eating certain foods, followed by exercise. As we examine more patients who have pollinosis, we have more opportunities to see allergic disease such as FDEIA, OAS, and so on. Methods: We performed a retrospective analysis of six cases, diagnosed FDEIA for this three years. Results: Of six cases, the ages are 8 to 47 years old, and the trigger allergens were wheat, shrimp, and grapefruit The trigger exercises were running, volleyball, as well as taking a bath. In four cases, the patients had history of allergic disease such as atopic dermatitis, allergic rhinitis, and so on. In two cases of wheat-dependent exercise-induced anaphylaxis, the IgE levels for ω5-gliadin (a major wheat allergen) in a RAST were positive. Conclusion: Of six cases diagnosed FDEIA, the trigger allergens were wheat, shrimp, and grape-fruit. In cases of wheat-dependent exercise-induced anaphylaxis, the IgE levels for ω5-gliadin in a RAST were positive. After the food allergen has been identified, we advised strict restrictions on in gestion of trigger allergens in the case of shrimp and grapefruit, and on any exercise after eating foods containing wheat flour in the case of wheat. ©2009 Japanese Society of Allergology.