Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein

mBio

Mizuki Yamamoto
Jin Gohda
Ayako Kobayashi
Keiko Tomita
Youko Hirayama
Naohiko Koshikawa
Motoharu Seiki
Kentaro Semba
Tetsu Akiyama
Yasushi Kawaguchi
Jun-ichiro Inoue

巻: 13
号: 4
開始ページ: e0051922
終了ページ
記述言語: 英語
掲載種別: 研究論文（学術雑誌）
DOI: 10.1128/mbio.00519-22
出版者・発行元: American Society for Microbiology

To develop effective therapeutics against COVID-19, it is necessary to elucidate in detail the infection mechanism of the causative agent, SARS-CoV-2. SARS-CoV-2 binds to the cell surface receptor ACE2 via the spike protein, and then the spike protein is cleaved by host proteases to enable entry.

リンク情報

DOI: https://doi.org/10.1128/mbio.00519-22
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/35708281
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426510
URL: https://journals.asm.org/doi/pdf/10.1128/mbio.00519-22

ID情報

DOI : 10.1128/mbio.00519-22
eISSN : 2150-7511
PubMed ID : 35708281
PubMed Central 記事ID : PMC9426510

エクスポート: BibTeX RIS

山本瑞生

論文

Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein

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