2013年6月4日
Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo
Proceedings of the National Academy of Sciences of the United States of America
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- 巻
- 110
- 号
- 23
- 開始ページ
- 9409
- 終了ページ
- 9414
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.1307419110
Posttranscriptional regulation of IL-6 has been largely uncharacterized, with the exception of the ribonuclease Regnase-1, which prevents autoimmunity by destabilizing IL-6 mRNA. Here, we identified AT-rich interactive domain-containing protein 5A (Arid5a) as a unique RNA binding protein, which stabilizes IL-6 but not TNF-α mRNA through binding to the 3' untranslated region of IL-6 mRNA. Arid5a was enhanced in macrophages in response to LPS, IL-1β, and IL-6. Arid5a deficiency inhibited elevation of IL-6 serum level in LPStreated mice and suppressed IL-6 levels and the development of T H17 cells in experimental autoimmune encephalomyelitis. Importantly, Arid5a inhibited the destabilizing effect of Regnase-1 on IL-6 mRNA. These results indicate that Arid5a plays an important role in promotion of inflammatory processes and autoimmune diseases.
- リンク情報
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- DOI
- https://doi.org/10.1073/pnas.1307419110
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23676272
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878696872&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84878696872&origin=inward
- ID情報
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- DOI : 10.1073/pnas.1307419110
- ISSN : 0027-8424
- eISSN : 1091-6490
- PubMed ID : 23676272
- SCOPUS ID : 84878696872