Mayumi Hirano

Profile Information

Affiliation: Assistant Professor, Faculty of Medical Sciences, Division of Molecular Cardiology, Kyushu University

Degree: Ph. D

J-GLOBAL ID: 200901093410688545
researchmap Member ID: 5000007392

血管内皮細胞に関する研究
１．内皮細胞収縮の制御機構
２．内皮細胞収縮および細胞間接着を介した透過性制御機構
３．細胞間接触による増殖抑制機構

Research Interests

Research Areas

Research History

Education

Committee Memberships

Papers

Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption

Mayumi Hirano, Katsuya Hirano

The Journal of Physiological Sciences, Dec, 2022
Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility.

Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

Digestive diseases and sciences, Aug 10, 2022
Increased lung uric acid deteriorates pulmonary arterial hypertension

Takanori Watanabe, Mariko Ishikawa, Kohtaro Abe, Tomohito Ishikawa, Satomi Imakiire, Kohei Masaki, Kazuya Hosokawa, Tomoko Fukuuchi, Kiyoko Kaneko, Toshio Ohtsubo, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui

Journal of the American Heart Association, 10(23), Dec 7, 2021
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.

Tomohito Ishikawa, Kohtaro Abe, Mariko Takana-Ishikawa, Keimei Yoshida, Takanori Watanabe, Satomi Imakiire, Kazuya Hosokawa, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui

Journal of the American Heart Association, 10(7) e019247, Apr 6, 2021
Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body

Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y

Eur J Pharmacol, 857 172405, May, 2019 Peer-reviewed
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K

Cadiovasc Res, published online(8) 1357-1368, Nov, 2018 Peer-reviewed
Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na⁺/Ca²⁺ Exchanger.

Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, Iwamoto T, Ogino H, Hirano M, Oda Y, Nakamura K, Ogawa Y

Cellular and molecular gastroenterology and hepatology, 5(3) 209-221, Mar, 2018 Peer-reviewed
Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body

Bai Xiaopeng, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Kayoko Nakano, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura

EUROPEAN JOURNAL OF PHARMACOLOGY, 797 65-74, Feb, 2017 Peer-reviewed
Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption

Mayumi Hirano, Katsuya Hirano

SCIENTIFIC REPORTS, 6(20989), Feb, 2016 Peer-reviewed
Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter

Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Shunsuke Takahashi, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Yoshinao Oda, Ryoichi Takayanagi

EUROPEAN JOURNAL OF PHARMACOLOGY, 752 97-105, Apr, 2015 Peer-reviewed
トロンビン受容体を標的とした脳血管攣縮予防

平野勝也, 平野真弓

日本臨牀, 72(Sppl5) 433-437, Jul, 2014
Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility

Toshiro Saito, Mayumi Hirano, Tomomi Ide, Toshihiro Ichiki, Noriyuki Koibuchi, Kenji Sunagawa, Katsuya Hirano

Circulation, 127(1) 104-114, Jan 1, 2013 Peer-reviewed
Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca2+ sensitization after subarachnoid hemorrhage

Yuichiro Kikkawa, Satoshi Matsuo, Katsuharu Kameda, Mayumi Hirano, Akira Nakamizo, Tomio Sasaki, Katsuya Hirano

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 32(2) 341-352, Feb, 2012 Peer-reviewed
Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage

Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Satoshi Matsuo, Tomio Sasaki, Katsuya Hirano

BRITISH JOURNAL OF PHARMACOLOGY, 165(1) 106-119, Jan, 2012 Peer-reviewed
くも膜下出血後の脳血管平滑筋収縮性亢進の分子機構

吉川雄一郎, 佐々木富男, 平野真弓, 平野勝也

福岡医学雑誌, 102(12) 325-332, Dec, 2011 Peer-reviewed
[Molecular mechanisms underlying the increased contractility of smooth muscle in cerebral artery after subarachnoid hemmorhage].

Kikkawa Y, Sasaki T, Hirano M, Hirano K

Fukuoka igaku zasshi = Hukuoka acta medica, 102 325-332, Dec, 2011 Peer-reviewed
Cilostazol Suppresses Angiotensin II-Induced Vasoconstriction via Protein Kinase A-Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel

Kinue Nishioka, Motohiro Nishida, Marina Ariyoshi, Zhong Jian, Shota Saiki, Mayumi Hirano, Michio Nakaya, Yoji Sato, Satomi Kita, Takahiro Iwamoto, Katsuya Hirano, Ryuji Inoue, Hitoshi Kurose

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(10) 2278-U304, Oct, 2011 Peer-reviewed
Involvement of Reactive Oxygen Species in Thrombin-induced Pulmonary Vasoconstriction

Jun Maki, Mayumi Hirano, Sumio Hoka, Hideo Kanaide, Katsuya Hirano

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 182(11) 1435-1444, Dec, 2010 Peer-reviewed
Current Perspective on the Role of the Thrombin Receptor in Cerebral Vasospasm After Subarachnoid Hemorrhage

Katsuya Hirano, Mayumi Hirano

JOURNAL OF PHARMACOLOGICAL SCIENCES, 114(2) 127-133, Oct, 2010 Peer-reviewed
Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage

Yuichiro Kikkawa, Katsuharu Kameda, Mayumi Hirano, Tomio Sasaki, Katsuya Hirano

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 30(9) 1637-1650, Sep, 2010 Peer-reviewed

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日本心脈管作動物質学会

Other

(香川県高松市 Japan), Feb 6, 2015 - Feb 7, 2015
第８８回日本薬理学会年会

Other

(仙台 Japan), Mar 19, 2014 - Mar 21, 2014

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Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Papers

Major Misc.

Major Books and Other Publications

Major Presentations

Teaching Experience

Professional Memberships

Research Projects

Academic Activities

Social Activities