論文

国際誌
2022年4月

Signaling domains of cancer-associated glycolipids.

Glycoconjugate journal
  • Koichi Furukawa
  • Yuhsuke Ohmi
  • Kazunori Hamamura
  • Yuji Kondo
  • Yuki Ohkawa
  • Kei Kaneko
  • Noboru Hashimoto
  • Farhana Yesmin
  • Robiul H Bhuiyan
  • Orie Tajima
  • Keiko Furukawa
  • 全て表示

39
2
開始ページ
145
終了ページ
155
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10719-022-10051-1

Immunotherapy of malignant cancers is now becoming one of representative approaches to overcome cancers. To construct strategies for immunotherapy, presence of tumor-specific antigens should be a major promise. A number of cancer specific- or cancer-associated antigens have been reported based on various experimental sets and various animal systems. The most reasonable strategy to define tumor-specific antigens might be "autologous typing" performed by Old's group, proposing three classes of tumor-antigens recognized by host immune systems of cancer patients. Namely, class 1, individual antigens that is present only in the patient's sample analyzed; class 2, shared antigens that can be found only in some group of cancers in some patients, but not in normal cells and tissues; class 3, universal antigens that are present in some cancers but also in normal cells and tissues with different densities. Sen Hakomori reported there were novel carbohydrates in cancers that could not be detected in normal cells mainly by biochemical approaches. Consequently, many of class 2 cancer-specific antigens have been revealed to be carbohydrate antigens, and been used for cancer diagnosis and treatment. Not only as cancer markers, but roles of those cancer-associated carbohydrates have also been recognized as functional molecules in cancer cells. In particular, roles of complex carbohydrates in the regulation of cell signaling on the cell surface microdomains, glycolipid-enriched microdomain (GEM)/rafts have been reported by Hakomori and many other researchers including us. The processes and present status of these studies on cancer-associated glycolipids were summarized.

リンク情報
DOI
https://doi.org/10.1007/s10719-022-10051-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35315508
ID情報
  • DOI : 10.1007/s10719-022-10051-1
  • PubMed ID : 35315508

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