Noboru Hashimoto

Profile Information

J-GLOBAL ID: 201901019337020656
researchmap Member ID: B000361641

Research Areas

Life sciences / Anatomy /

Papers

Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia.

Fumiya Kano, Noboru Hashimoto, Yao Liu, Linze Xia, Takaaki Nishihara, Wakana Oki, Keita Kawarabayashi, Noriko Mizusawa, Keiko Aota, Takayoshi Sakai …

Scientific reports, 13(1) 2706-2706, Feb 15, 2023 Peer-reviewed
Signaling domains of cancer-associated glycolipids.

Koichi Furukawa, Yuhsuke Ohmi, Kazunori Hamamura, Yuji Kondo, Yuki Ohkawa, Kei Kaneko, Noboru Hashimoto, Farhana Yesmin, Robiul H Bhuiyan, Orie Tajima …

Glycoconjugate journal, 39(2) 145-155, Apr, 2022
Conditioned Medium From the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Neuropathic Pain in a Partial Sciatic Nerve Ligation Model.

Yao Liu, Fumiya Kano, Noboru Hashimoto, Linze Xia, Qiao Zhou, Xingmei Feng, Hideharu Hibi, Aya Miyazaki, Tsutomu Iwamoto, Yoshizo Matsuka …

Frontiers in pharmacology, 13 745020-745020, 2022
Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model

Yuki Ohkawa, Pu Zhang, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yuhsuke Ohmi, Robiul H. Bhuiyan, Yesmin Farhana, Atsushi Natsume, Toshihiko Wakabayashi …

Cancer Science, Jun 30, 2021
Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review

Eiji Tanaka, Yao Liu, Linze Xia, Naoko Ogasawara, Takuma Sakamaki, Fumiya Kano, Noboru Hashimoto, Xingmei Feng, Akihito Yamamoto

Annals of Biomedical Engineering, Jun 8, 2020 Peer-reviewed
Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental temporomandibular joint osteoarthritis

N. Ogasawara, F. Kano, N. Hashimoto, H. Mori, Y. Liu, L. Xia, T. Sakamaki, H. Hibi, T. Iwamoto, E. Tanaka …

Osteoarthritis and Cartilage, 28(6) 831-841, Jun, 2020
Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering.

Koichi Furukawa, Yuhsuke Ohmi, Farhana Yesmin, Orie Tajima, Yuji Kondo, Pu Zhang, Noboru Hashimoto, Yuki Ohkawa, Robiul H Bhuiyan, Keiko Furukawa

International journal of molecular sciences, 21(6), Mar 11, 2020 Peer-reviewed
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.

Noboru Hashimoto, Shizuka Ito, Akiko Tsuchida, Robiul H Bhuiyan, Tetsuya Okajima, Akihito Yamamoto, Keiko Furukawa, Yuhsuke Ohmi, Koichi Furukawa

The Journal of biological chemistry, 294(28) 10833-10845, Jul 12, 2019 Peer-reviewed
New era of research on cancer-associated glycosphingolipids.

Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Robiul H Bhuiyan, Pu Zhang, Orie Tajima, Noboru Hashimoto, Kazunori Hamamura, Keiko Furukawa

Cancer science, 110(5) 1544-1551, May, 2019 Peer-reviewed
Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice.

Robiul H Bhuiyan, Yuhsuke Ohmi, Yuki Ohkawa, Pu Zhang, Maiko Takano, Noboru Hashimoto, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa

Neuroscience, 397 94-106, Jan 15, 2019 Peer-reviewed
ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer.

Nobutoshi Esaki, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Tsuda, Yuhsuke Ohmi, Robiul H Bhuiyan, Norihiro Kotani, Koichi Honke, Atsushi Enomoto, Masahide Takahashi …

Cancer science, 109(1) 141-153, Jan, 2018 Peer-reviewed
Gangliosides in Inflammation and Neurodegeneration.

Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Yuji Kondo, Ji Shuting, Noboru Hashimoto, Keiko Furukawa

Progress in molecular biology and translational science, 156 265-287, 2018 Peer-reviewed
Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis

Koichi Furukawa, Yuhsuke Ohmi, Shuting Ji, Pu Zhang, Robiul H. Bhuiyan, Yuki Ohkawa, Orie Tajima, Noboru Hashimoto, Keiko Furukawa

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1861(10) 2479-2484, Oct, 2017 Peer-reviewed
Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes

Robiul Hasan Bhuiyan, Yuji Kondo, Tokiaki Yamaguchi, Noriyo Tokuda, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Ohmi, Yoshio Yamauchi, Keiko Furukawa, Tetsuya Okajima …

GLYCOBIOLOGY, 26(9) 984-998, Sep, 2016 Peer-reviewed
Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells

Kei Kaneko, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Ohmi, Norihiro Kotani, Koichi Honke, Mitsutaka Ogawa, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(32) 16630-16643, Aug, 2016 Peer-reviewed
Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies

Reiko Ando, Noriyo Tokuda, Tokunori Yamamoto, Kazutaka Ikeda, Noboru Hashimoto, Ryo Taguchi, Xiaoen Fan, Keiko Furukawa, Yukio Niimura, Akemi Suzuki …

GLYCOCONJUGATE JOURNAL, 33(2) 169-180, Apr, 2016 Peer-reviewed
Regulatory mechanisms for malignant properties of cancer cells with disialyl and monosialyl gangliosides

Koichi Furukawa, Yuki Ohkawa, Keiko Furukawa, Yasuyuki Matsumoto, Yuhsuke Ohmi, Noboru Hashimoto

Glycosignals in Cancer: Mechanisms of Malignant Phenotypes, 57-76, Jan 1, 2016 Peer-reviewed
Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor and Yes Kinase

Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yusuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi …

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(26) 16043-16058, Jun, 2015 Peer-reviewed
Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Promote Recovery after Rat Spinal Cord Injury by Altering Macrophage Polarity

Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura …

JOURNAL OF NEUROSCIENCE, 35(6) 2452-2464, Feb, 2015 Peer-reviewed
Gangliosides: Synthesis and function in nervous tissues

Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Noboru Hashimoto, Yoshio Yamauchi, Orie Tajima, Keiko Furukawa

Glycoscience: Biology and Medicine, 551-556, Jan 1, 2015 Peer-reviewed

Misc.

シグナル伝達を制御する糖・糖鎖糖脂質糖鎖よるシグナル制御のメカニズム

古川鋼一, 大川祐樹, 大海雄介, 橋本登, 古川圭子

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [4W16-3], Dec, 2015
TLC-LESA-QTRAP6500によるSiglec-7特異的認識ganglioside GD3の構造解析

橋本登, 伊藤静香, 池田和貴, 土田明子, Crocker Paul R, 古川圭子, 田口良, 古川鋼一

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2T特-07(2P0324)], Dec, 2015
ヒトmelanoma細胞におけるNeogenin細胞内ドメイン(NeICD)標的遺伝子の同定

金子慶, 大川祐樹, 橋本登, 大海雄介, 山内祥生, 岡島徹也, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本癌学会総会記事, 74回 E-1081, Oct, 2015
がん関連糖鎖がんマーカーとしての有用性と生物学的意義の統合的理解癌関連糖鎖との協同作用により癌形質を発現する分子群の同定と作用機構

古川鋼一, 大川祐樹, 橋本登, 金子慶, 小谷典弘, 本家孝一, 大海雄介, 古川圭子

日本癌学会総会記事, 74回 S20-4, Oct, 2015
ガングリオシドGD3の発現はグリオーマの発生・進展を促進する

大川祐樹, 百田洋之, 加藤彰, 橋本登, 津田裕介, 江崎寛季, 古川圭子, 大海雄介, 夏目敦至, 若林俊彦 …

日本癌学会総会記事, 74回 E-1353, Oct, 2015
Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice

Hirotaka Wakayama, Naozumi Hashimoto, Yoshihiro Matsushita, Kohki Matsubara, Noriyuki Yamamoto, Yoshinori Hasegawa, Minoru Ueda, Akihito Yamamoto

CYTOTHERAPY, 17(8) 1119-1129, Aug, 2015
Proteomic analysis of ganglioside-associated microdomain in malignant melanomas

Noboru Hashimoto, Kazunori Hamamura, Norihiro Kotani, Keiko Furukawa, Kei Kaneko, Koichi Honke, Koichi Furukawa

GLYCOBIOLOGY, 24(11) 1220-1220, Nov, 2014
Modulation of malignant properties of cancer cells by binding of a sialic acid-recognizing lectin Siglec-9 via calpain-mediated degradation of focal adhesion kinase and related proteins

Koichi Furukawa, Ilhamjan Sabit, Noboru Hashimoto, Yasuyuki Matsumoto, Toshiyuki Yamaji, Keiko Furukawa

GLYCOBIOLOGY, 24(11) 1145-1146, Nov, 2014
GD3発現メラノーマにおけるNeogeninの悪性形質創出メカニズム

金子慶, 大川祐樹, 橋本登, 大海雄介, 小川光貴, 山内祥生, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 87回 [3T16a-05], Oct, 2014
ガングリオシドによるAPP切断とその切断断片による酸化ストレス応答の制御

山口世堯, 山内祥生, 松本康之, 橋本登, 大海雄介, 近藤裕史, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 87回 [4P-040], Oct, 2014
ガングリオシドGD3はPDGFRαと協調しYesの活性化を介して細胞浸潤能を亢進させる(Ganglioside GD3 enhances invasion activity by forming a complex of PDGFRα and Yes kinase in PDGFB-transfected astrocytes)

大川祐樹, 百田洋之, 加藤彰, 橋本登, 津田裕介, 大海雄介, 古川圭子, 夏目敦至, 若林俊彦, 古川鋼一

日本癌学会総会記事, 73回 J-3095, Sep, 2014
GD3発現ヒトメラノーマ細胞におけるNeogeninの役割(Roles of Neogenin in GD3-expressing human melanoma cells)

金子慶, 大川祐樹, 橋本登, 大海雄介, 山内祥生, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本癌学会総会記事, 72回 140-140, Oct, 2013
GD3発現メラノーマの悪性形質におけるNeogeninの機能(Implication of Neogenin in the malignant properties of GD3-expressing melanoma cells)

金子慶, 大川祐樹, 橋本登, 大海雄介, 山内祥生, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 86回 1T06p-03, Sep, 2013
ガングリオシドによるamyloid β precursor protein(APP)の切断パターンの制御及びAPP切断断片が細胞の健常性に与える影響

山口世堯, 山内祥生, 松本康之, 大川祐樹, 大海雄介, 橋本登, 近藤裕史, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 86回 1P-439, Sep, 2013
【第三の生命鎖糖鎖の機能と疾患がん、糖尿病、筋ジストロフィー発症との関わりからマーカー・合成法の開発、技術革新まで】(第1章)作動原理と疾患、生命現象とのかかわりがんがん関連抗原としてのガングリオシド

古川鋼一, 大川祐樹, 橋本登, 大海雄介, 古川圭子

実験医学, 31(10) 1539-1544, Jun, 2013
GD3近傍分子として同定されたNeogeninのメラノーマ細胞における機能解析

金子慶, 大川祐樹, 橋本登, 大海雄介, 山内祥生, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 85回 2P-062, Dec, 2012
メラノーマの悪性形質における癌関連ガングリオシドの機能に関する統合的理解(Total analyses on the roles of cancer-associated gangliosides in malignant properties of melanomas)

山内祥生, 浜村和紀, 大川祐樹, 橋本登, 大海雄介, 古川圭子, 古川鋼一

日本癌学会総会記事, 70回 220-220, Sep, 2011
メラノーマ抗原GD3の発現によるNeogeninの局在変化と機能解析(Distribution and function analyses of Neogenin under the expression of GD3 in melanoma)

金子慶, 大川祐樹, 大海雄介, 橋本登, 山内祥生, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本癌学会総会記事, 70回 327-327, Sep, 2011
メラノーマの細胞膜におけるガングリオシドGD3含有ミクロドメイン上のタンパク質分子の網羅的解析

橋本登, 金子慶, 大川祐樹, 大海雄介, 濱村和紀, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 84回 2P-0038, Sep, 2011
メラノーマ抗原GD3の発現によるNeogeninの局在変化と機能解析(Distribution and function of Neogenin under the expression of GD3 in melanoma)

金子慶, 大川祐樹, 大海雄介, 橋本登, 山内祥生, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一

日本生化学会大会プログラム・講演要旨集, 84回 2P-0039, Sep, 2011

Research Projects

Analysis of joint regeneration mechanism by secretory sialic acid recognition lectin

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
乳歯歯髄幹細胞培養上清由来因子を用いた新規皮膚炎治療法の検討

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

橋本登, 加納史也, 杉浦一充
Analysis of transition from inflammation to regeneration of myeloide cell regulated soluble Siglec-9 and MCP-1

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

HASHIMOTO Noboru
Mechanisms for innate immune check-point generated by siglecs and sialic acid-containing carbohydrates

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

FURUKAWA Koichi
Functional analysis of gangliosides in invasion front in early stage glioma

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

OHKAWA Yuki, FURUKAWA Koichi, MOMOTA Hiroyuki, NATSUME Atsushi, WAKABAYASHI Toshihiko, KATO Akira, HASHIMOTO Noboru
Sialoglycan facilitate cancer escape from immunosurveillance via sialic acid-binding Siglec-7 on NK cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Hashimoto Noboru

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