Norio Kobayashi

Profile Information

Affiliation: Postdoctoral Fellow, Department of Mechanical Engineering, University of Michigan

Degree: 農学(東北大学)

Researcher number: 10803885
J-GLOBAL ID: 201801009499241050
researchmap Member ID: B000344449

Research Areas

Life sciences / Developmental biology /

Research History

Jul, 2022 - Present

Postdoctoral Fellow, Department of Mechanical Engineering, University of Michigan
Oct, 2018 - Jun, 2022

Assistant Professor, Graduate School of Medicine, Tohoku University
Apr, 2017 - Sep, 2018

Postdoctoral Fellow, Graduate School of Medicine, Tohoku University

Education

Apr, 2012 - Mar, 2017

農学研究科, 東北大学大学院
Apr, 2008 - Mar, 2012

Department of Applied Bio-Sciences, Faculty of Agriculture, Tohoku University

Awards

Aug, 2016

Young Scientists Award/JSAS Excellent Presentation Award, The 17th AAAP Societies Animal Science Congress,

Norio Kobayashi

Papers

A Patterned Human Neural Tube Model Using Microfluidic Gradients.

Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng …

Nature, Feb 26, 2024 Peer-reviewed
Modeling embryo-endometrial interface recapitulating human embryo implantation

Shun Shibata, Shun Endo, Luis A. E. Nagai, Eri H. Kobayashi, Akira Oike, Norio Kobayashi, Akane Kitamura, Takeshi Hori, Yuji Nashimoto, Ryuichiro Nakato …

Science Advances, 10(8), Feb 23, 2024 Peer-reviewed
Trophoblast stem cell-based organoid models of the human placental barrier.

Takeshi Hori, Hiroaki Okae, Shun Shibata, Norio Kobayashi, Eri H Kobayashi, Akira Oike, Asato Sekiya, Takahiro Arima, Hirokazu Kaji

Nature communications, 15(1) 962-962, Feb 8, 2024 Peer-reviewed
Derivation of human primordial germ cell-like cells in an embryonic-like culture.

Sajedeh Nasr Esfahani, Yi Zheng, Auriana Arabpour, Agnes M Resto Irizarry, Norio Kobayashi, Xufeng Xue, Yue Shao, Cheng Zhao, Nicole L Agranonik, Megan Sparrow …

Nature communications, 15(1) 167-167, Jan 2, 2024 Peer-reviewed
CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development.

Takanori Shimizu, Akira Oike, Eri H Kobayashi, Asato Sekiya, Norio Kobayashi, Shun Shibata, Hirotaka Hamada, Masatoshi Saito, Nobuo Yaegashi, Mikita Suyama …

Proceedings of the National Academy of Sciences of the United States of America, 120(51) e2311372120, Dec 19, 2023 Peer-reviewed
Morphogenesis beyond in vivo

Yue Liu, Xufeng Xue, Shiyu Sun, Norio Kobayashi, Yung Su Kim, Jianping Fu

Nature Reviews Physics, 6(1) 28-44, Dec 11, 2023 Peer-reviewed
Stem cell-derived embryo models: a frontier of human embryology

Norio Kobayashi, Jianping Fu

Medical Review, 3(4) 343-346, Aug 1, 2023 Peer-reviewedLead author
Genomic imprinting in human placentation.

Eri H Kobayashi, Shun Shibata, Akira Oike, Norio Kobayashi, Hirotaka Hamada, Hiroaki Okae, Takahiro Arima

Reproductive medicine and biology, 21(1) e12490, Dec, 2022 Peer-reviewed
The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells.

Norio Kobayashi, Hiroaki Okae, Hitoshi Hiura, Naoto Kubota, Eri H Kobayashi, Shun Shibata, Akira Oike, Takeshi Hori, Chie Kikutake, Hirotaka Hamada …

Nature communications, 13(1) 3071-3071, Jun 2, 2022 Peer-reviewedLead author
Unique features and emerging in vitro models of human placental development

Shun Shibata, Eri H. Kobayashi, Norio Kobayashi, Akira Oike, Hiroaki Okae, Takahiro Arima

Reproductive Medicine and Biology, 19(4) 301-313, Oct, 2020 Peer-reviewed
Loss of p57^KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells.

Takahashi S, Okae H, Kobayashi N, Kitamura A, Kumada K, Yaegashi N, Arima T

Proceedings of the National Academy of Sciences of the United States of America, 116(52) 26606-26613, Dec, 2019 Peer-reviewed
The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study.

Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro …

Reproductive biology and endocrinology : RB&E, 17(1) 27-27, Feb 22, 2019 Peer-reviewed
Association of four imprinting disorders and ART.

Hiromitsu Hattori, Hitoshi Hiura, Akane Kitamura, Naoko Miyauchi, Norio Kobayashi, Souta Takahashi, Hiroaki Okae, Koichi Kyono, Masayo Kagami, Tsutomu Ogata …

Clinical epigenetics, 11(1) 21-21, Feb 7, 2019 Peer-reviewed
Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer

Hitoshi Hiura, Hiromitsu Hattori, Norio Kobayashi, Hiroaki Okae, Hatsune Chiba, Naoko Miyauchi, Akane Kitamura, Hiroyuki Kikuchi, Hiroaki Yoshida, Takahiro Arima

Clinical Epigenetics, 9(1) 79, Aug 3, 2017 Peer-reviewed
Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence.

Satoshi Sugimura, Norio Kobayashi, Hiroaki Okae, Tadayuki Yamanouchi, Hideo Matsuda, Takumi Kojima, Akira Yajima, Yutaka Hashiyada, Masahiro Kaneda, Kan Sato …

Scientific reports, 7(1) 6815-6815, Jul 28, 2017 Peer-reviewedLead author
Factors associated with aberrant imprint methylation and oligozoospermia

Norio Kobayashi, Naoko Miyauchi, Nozomi Tatsuta, Akane Kitamura, Hiroaki Okae, Hitoshi Hiura, Akiko Sato, Takafumi Utsunomiya, Nobuo Yaegashi, Kunihiko Nakai …

SCIENTIFIC REPORTS, 7 42336, Feb, 2017 Peer-reviewedLead author
Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa

Norio Kobayashi, Hiroaki Okae, Hitoshi Hiura, Hatsune Chiba, Yoshiki Shirakata, Kenshiro Hara, Kentaro Tanemura, Takahiro Arima

PLOS ONE, 11(11) e0167127, Nov, 2016 Peer-reviewedLead author
Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice

Kei Nakano, Manami Nishio, Norio Kobayashi, Yuuki Hiradate, Yumi Hoshino, Eimei Sato, Kentaro Tanemura

ZYGOTE, 24(2) 172-180, Apr, 2016 Peer-reviewed
Distribution of the sex chromosome during mouse spermatogenesis in testis tissue sections

Kosuke Otaka, Yuuki Hiradate, Norio Kobayashi, Yoshiki Shirakata, Kentaro Tanemura

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 61(5) 375-381, Oct, 2015 Peer-reviewed
Neurotensin Enhances Sperm Capacitation and Acrosome Reaction in Mice

Yuuki Hiradate, Hiroki Inoue, Norio Kobayashi, Yoshiki Shirakata, Yutaka Suzuki, Aina Gotoh, Sang-gun Roh, Takafumi Uchida, Kazuo Katoh, Manabu Yoshida …

BIOLOGY OF REPRODUCTION, 91(2) 53, Aug, 2014 Peer-reviewed

Misc.

ヒト栄養膜細胞の浸潤を再現した胎盤チップモデル

堀武志, 天野倉大成, 岡江寛明, 小林記緒, 有馬隆博, 梶弘和

化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM), 45th, 2022
妊娠高血圧症候群における細胞性栄養膜細胞を用いたマルチオミックス解析

遠藤俊, 遠藤俊, 柴田峻, 小林枝里, 清水孝規, 清水孝規, 大池輝, 小林記緒, 岡江寛明, 濱田裕貴 …

日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集, 40th-30th (CD-ROM), 2022
Establishment of Placental disease models by human TS cells

大池輝, 小林枝里, 小林記緒, 柴田峻, 岡江寛明, 北村茜, 宮内尚子, 有馬隆博

Bio Clinica, 36(5), 2021
Development of the human placental model using microfluidics device

天野倉大成, 堀武志, 小林記緒, 岡江寛明, 有馬隆博, 梶弘和

日本バイオマテリアル学会大会予稿集(Web), 43rd, 2021
Development of a microfluidic device for functional evaluation of the human placenta

天野倉大成, 堀武志, 小林記緒, 岡江寛明, 有馬隆博, 梶弘和

応用物理学会秋季学術講演会講演予稿集(CD-ROM), 82nd, 2021
ヒト胎盤モデル構築に向けたマイクロ流路デバイスの開発

天野倉大成, 堀武志, 小林記緒, 岡江寛明, 有馬隆博, 梶弘和

化学とマイクロ・ナノシステム学会研究会講演要旨集, 42nd (Web), 2020
ヒト胎盤モデル構築に向けたマイクロ流路デバイスの開発

天野倉大成, 堀武志, 小林記緒, 岡江寛明, 有馬隆博, 梶弘和

電気化学会東北支部セミコンファレンス・東北若手の会(CD-ROM), 51st, 2020

Books and Other Publications

Genomic imprinting and human placenta

(Role: Joint author)

Jan, 2020
ART治療法における遺伝的安全性とリスク（月刊細胞 51(5)）

宮内尚子, 服部裕充, 小林記緒, 樋浦仁, 有馬隆博 (Role: Joint author)

ニュー・サイエンス社、北隆館, May, 2019
Therapeutic approaches to imprinting diseases.

Hattori H, Hiura H, Kobayashi Norio, Takahashi Sota, Okae Hiroaki, Arima Takahiro (Role: Joint author)

Academic Press, 2018

Research Projects

ヒト胎盤特異的なインプリント遺伝子C19MCの発現制御因子の解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

小林記緒
ヒト胎盤形成のエピゲノム制御と母体－胎盤間分子シグナルコミュニケーションの理解

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2021 - Mar, 2025

有馬隆博, 小林記緒, 柴田峻, 小林枝里
凍結胚移植法によるART出生児の神経行動学的発達に及ぼす影響についての実証的研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

宮内尚子, 小林記緒, 小林枝里
ヒト胎盤幹細胞を用いた胚着床オルガノイドの創出と着床不全細胞治療への挑戦

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2023

有馬隆博, 小林記緒, 小林枝里
ヒトES細胞から胚体外細胞系譜への分化転換に伴う分子機構の解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2019 - Mar, 2022

小林記緒
ヒトES細胞の分化転換による胎盤発生のエピゲノム制御機構

笹川科学研究助成, 学術研究部門（生物系）, 公益財団法人日本科学協会, Apr, 2020 - Feb, 2021
Epigenetics of Next-Generation Inheritance in Sperm Aging

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2017 - Mar, 2019

Kobayashi Norio

Profile Information

Research Areas

Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Research Projects

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